Mouse Schwann cells activate MHC class I and II restricted T-cell responses, but require external peptide processing for MHC class II presentation

Neurobiology of Disease
Gerd Meyer zu HorsteB C Kieseier

Abstract

Schwann cells are the myelinating glia cells of the peripheral nervous system (PNS). In inflammatory neuropathies like the Guillain-Barré syndrome (GBS) Schwann cells become target of an autoimmune response, but may also modulate local inflammation. Here, we tested the functional relevance of Schwann cell derived MHC expression in an in vitro coculture system. Mouse Schwann cells activated proliferation of ovalbumin specific CD8+ T cells when ovalbumin protein or MHC class I restricted ovalbumin peptide (Ova(257-264) SIINFEKL) was added and after transfection with an ovalbumin coding vector. Schwann cells activated proliferation of ovalbumin specific CD4+ T cells in the presence of MHC class II restricted ovalbumin peptide (Ova(323-339) ISQAVHAAHAEINEAGR). CD4+ T-cell proliferation was not activated by ovalbumin protein or transfection with an ovalbumin coding vector. This indicates that Schwann cells express functionally active MHC class I and II molecules. In this study, however, Schwann cells lacked the ability to process exogenous antigen or cross-present endogenous antigen into the MHC class II presentation pathway. Thus, antigen presentation may be a pathological function of Schwann cells exacerbating nerve damage in infl...Continue Reading

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Citations

Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hannah V SiddleJim Kaufman
Apr 18, 2014·Journal of Clinical Immunology·Nevena TzekovaPatrick Küry
Apr 1, 2014·Journal of Neuroinflammation·Mark StettnerBernd C Kieseier
Mar 26, 2013·Neurobiology of Disease·Elke YdensSophie Janssens
Sep 18, 2018·The Journal of Clinical Investigation·Denise E AllardMaureen A Su
Nov 5, 2019·Cancer Immunology, Immunotherapy : CII·Sophia H ZhangYuri L Bunimovich
May 8, 2020·Journal of Neuroinflammation·Thomas GrüterKalliopi Pitarokoili
Apr 28, 2017·Cellular and Molecular Neurobiology·Mark StettnerBernd C Kieseier
Apr 12, 2019·Frontiers in Cellular Neuroscience·Zhongya WeiGang Chen
Oct 13, 2018·Nature Reviews. Disease Primers·Bernd C KieseierHans-Peter Hartung
Oct 4, 2017·Scientific Reports·Maike HartlehnertGerd Meyer Zu Horste
Apr 11, 2018·Cancer Cell·Maximilian R StammnitzElizabeth P Murchison
Sep 3, 2021·Neural Regeneration Research·Kelly C S RoballoJared S Bushman
Dec 19, 2021·Journal of Neuroinflammation·Fabian SzepanowskiMark Stettner
Jan 13, 2022·Neural Regeneration Research·Igor JakovcevskiMelitta Schachner

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