Mouse Skull Mean Shape and Shape Robustness Rely on Different Genetic Architectures and Different Loci

Frontiers in Genetics
Ceferino Varón-GonzálezNicolas Navarro

Abstract

The genetic architecture of skull shape has been extensively studied in mice and the results suggest a highly polygenic and additive basis. In contrast few studies have explored the genetic basis of the skull variability. Canalization and developmental stability are the two components of phenotypic robustness. They have been proposed to be emergent properties of the genetic networks underlying the development of the trait itself, but this hypothesis has been rarely tested empirically. Here we use outbred mice to investigate the genetic architecture of canalization of the skull shape by implementing a genome-wide marginal epistatic test on 3D geometric morphometric data. The same data set had been used previously to explore the genetic architecture of the skull mean shape and its developmental stability. Here, we address two questions: (1) Are changes in mean shape and changes in shape variance associated with the same genomic regions? and (2) Do canalization and developmental stability rely on the same loci and genetic architecture and do they involve the same patterns of shape variation? We found that unlike skull mean shape, among-individual shape variance and fluctuating asymmetry (FA) show a total lack of additive effects. ...Continue Reading

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Citations

Mar 30, 2019·Journal of Evolutionary Biology·María Alejandra Petino ZappalaJuan José Fanara
Feb 17, 2021·PLoS Computational Biology·Philipp Mitteroecker, Ekaterina Stansfield
Jun 7, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elizabeth JewlalKatherine E Willmore

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