Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma

Frontiers in Oncology
Qiang LiYanhong Ni

Abstract

Preclinical animal models of oral squamous cell carcinoma (OSCC) have been extensively studied in recent years. Investigating the pathogenesis and potential therapeutic strategies of OSCC is required to further progress in this field, and a suitable research animal model that reflects the intricacies of cancer biology is crucial. Of the animal models established for the study of cancers, mouse tumor-bearing models are among the most popular and widely deployed for their high fertility, low cost, and molecular and physiological similarity to humans, as well as the ease of rearing experimental mice. Currently, the different methods of establishing OSCC mouse models can be divided into three categories: chemical carcinogen-induced, transplanted and genetically engineered mouse models. Each of these methods has unique advantages and limitations, and the appropriate application of these techniques in OSCC research deserves our attention. Therefore, this review comprehensively investigates and summarizes the tumorigenesis mechanisms, characteristics, establishment methods, and current applications of OSCC mouse models in published papers. The objective of this review is to provide foundations and considerations for choosing suitable ...Continue Reading

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Citations

Jun 23, 2020·Oral Diseases·Yanhong NiLorraine A O'Reilly
Aug 9, 2020·Oral Diseases·Sabrina MarcazzanMauro Ferrari
Jan 1, 2021·Frontiers in Pharmacology·Jorge B Pineda-FariasNicole N Scheff
Jun 15, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sheng-Hai CuiYan Yan

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Methods Mentioned

BETA
xenograft
immunoprecipitation
xenografts
targeted mutation
dissections
gene knockout
transgenic

Software Mentioned

XactMice

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