Mouse Tumor Models for Advanced Cancer Immunotherapy.

International Journal of Molecular Sciences
Daria S ChulpanovaValeriya V Solovyeva

Abstract

Recent advances in the development of new methods of cancer immunotherapy require the production of complex cancer animal models that reliably reflect the complexity of the tumor and its microenvironment. Mice are good animals to create tumor models because they are low cost, have a short reproductive cycle, exhibit high tumor growth rates, and can be easily genetically modified. However, the obvious problem of these models is the high failure rate observed in human clinical trials after promising results obtained in mouse models. In order to increase the reliability of the results obtained in mice, the tumor model should reflect the heterogeneity of the tumor, contain components of the tumor microenvironment, in particular immune cells, to which the action of immunotherapeutic drugs are directed. This review discusses the current immunocompetent and immunocompromised mouse models of human tumors that are used to evaluate the effectiveness of immunotherapeutic agents, in particular chimeric antigen receptor (CAR) T-cells and immune checkpoint inhibitors.

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Citations

Sep 27, 2020·Cancers·Zarema GilazievaValeriya Solovyeva
Mar 7, 2021·Cancers·Aleksei TitovEmil Bulatov
Mar 23, 2021·Current Opinion in Immunology·Trisha R Berger, Marcela V Maus
Apr 3, 2021·Advanced Drug Delivery Reviews·Paz Boix-MontesinosMaría J Vicent
Apr 3, 2021·Advanced Drug Delivery Reviews·Tengku Ibrahim MaulanaPeter Loskill
Apr 4, 2021·Cells·William H HicksKalil G Abdullah
Apr 4, 2021·International Journal of Molecular Sciences·Zhen ZengJames W Wells
Apr 26, 2021·Advanced Drug Delivery Reviews·Marcel A HeinrichJai Prakash
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Jan 14, 2022·Journal for Immunotherapy of Cancer·Maryland Rosenfeld FranklinSteven Anderson

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Methods Mentioned

BETA
genetic modification
transgenic
xenograft
xenografts

Software Mentioned

GEEMs

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