Mouse virulence of K(L) antigen-containing strains of Escherichia coli.

Journal of Bacteriology
G Wolberg, C W DeWitt

Abstract

The mouse virulence of two K antigen-containing (L variety) strains of Escherichia coli (serotype O2:K1) isolated from human septicemia, and of their variants which lacked K antigen, was studied. The strains containing envelope antigen (K+) were highly virulent when injected intracerebrally or when suspended in mucin and injected intraperitoneally. After intraperitoneal injection of E-107 K+ (but not K-), there was a marked initial growth in the peritoneal cavity followed by bacteremia and infection of all the organs examined. In the mucin-enhanced lethal infection, this growth continued until death of the animal; in the nonlethal infection, growth ceased and the count dropped quickly after approximately 5 hr. Host defenses were depressed greatly by intraperitoneally, but not intravenously, administered mucin. Bacteria were most virulent when injected intraperitoneally. In vitro phagocytosis of the K+ bacteria required opsonins not needed for phagocytosis of the smooth K- variants. Opsonins were found in immunized rabbit and normal mouse sera. Immune rabbit sera contained antibodies with anti-K specificity which were opsonic in vitro and highly protective in vivo when administered passively. There appears to be a lesser anti-O ...Continue Reading

References

Sep 1, 1968·The Journal of Experimental Medicine·D N MedearisE C Heath
Mar 1, 1966·Journal of Bacteriology·R Bolaños, C W DeWitt
Feb 1, 1966·The Journal of Experimental Medicine·J G Michael
Mar 1, 1953·The Biochemical Journal·H SMITH, R C GALLOP
Jan 13, 1956·Science·L H MUSCHEL, T MUTO
Oct 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·M FORBES, N A KUCK
Dec 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·J P STEWARD, R J ROANTREE
Mar 1, 1967·Journal of Bacteriology·T M Jacks, P J Glantz

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Citations

Jan 1, 1979·Scandinavian Journal of Infectious Diseases·W D WelchL S Young
Jan 1, 1972·Scandinavian Journal of Immunology·B KaijserL A Hanson
Jan 1, 1972·Acta Pathologica Et Microbiologica Scandinavica. Section B: Microbiology and Immunology·B KaijserS Seeberg
Sep 26, 1973·Medical Microbiology and Immunology·W SietzenH Hauk
Feb 1, 1982·Environmental Health Perspectives·S G Bradley, P S Morahan
May 30, 1974·The New England Journal of Medicine·J B RobbinsL A Hanson
Aug 1, 1983·Infection and Immunity·G T CostelloG T Rodeheaver
Sep 1, 1982·Infection and Immunity·S OpalP Gemski
Nov 1, 1978·Infection and Immunity·R BortolussiL W Wannamaker
Nov 1, 1970·Infection and Immunity·M NakamuraW R Cross

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