PMID: 9537042Jan 1, 1980Paper

Mouse/human T-cell hybrids rosetting with sheep erythrocytes

Scandinavian Journal of Immunology
H A SuomalainenJ Schröder

Abstract

Hybrid cells have been recovered from selective culture medium after fusion of concanavalin-A-activated human lymphocytes with an AKR mouse thymoma (BW 5147). After 6 months of culture twenty-seven out of forty-nine clones still contained human chromosomes. Human chromosome 6 was present in 89% of these clones, and human X in 70%. Clones from one hybrid line contained several human chromosomes. In twelve of the clones carrying human chromosomes, the rosetting with sheep erythrocytes (SRBC) was 3 times as high as in the BW 5147 cell line. All these clones carried the human chromosome 6, and eight clones contained the human X chromosome as well. In some of these clones (25%) chromosome 6 was the only human one present. In the two clones in which human chromosome 6 was completely missing, the rosetting with SRBC was at the level of the BW line. We therefore suggest that genes on human chromosome 6 are responsible for rosetting with SRBC.

Citations

May 1, 1985·Somatic Cell and Molecular Genetics·H A SuomalainenJ Schröder
Nov 1, 1980·Somatic Cell Genetics·P GoodfellowA McMichael
Nov 1, 1983·Somatic Cell Genetics·H A SuomalainenJ Schröder
May 1, 1986·Somatic Cell and Molecular Genetics·H A SuomalainenJ Schröder
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J SchröderL A Herzenberg
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A H Geurts van KesselD Bootsma
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T S WangD Korn
Apr 1, 1987·Scandinavian Journal of Immunology·H A Suomalainen-NevanlinnaL C Andersson
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·A P Dalmasso
May 13, 2008·The Journal of Infectious Diseases·Daniel M WeinbergerMarc Lipsitch
May 7, 2011·Journal of Microencapsulation·Tuhin BhowmikMartin J D'Souza
Jul 20, 2006·Journal of the Royal Society, Interface·Tomás Alarcón, Karen M Page
Apr 18, 2002·Proceedings. Biological Sciences·Jens Rolff
Aug 1, 1995·Journal of Endovascular Surgery : the Official Journal of the International Society for Endovascular Surgery·A E Bray
Feb 1, 1989·European Journal of Immunology·U H ForsbergJ Schröder
Jan 1, 1981·Hereditas·J SchröderH A Suomalainen

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