Movement disorder society criteria for clinically established early Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Daniela BergRonald B Postuma

Abstract

In 2015, the International Parkinson and Movement Disorder Society published clinical diagnostic criteria for Parkinson's disease (PD). Although recent validation studies suggest high accuracy, one unmet need is for highly specific criteria for clinical trials in early/de novo PD. The objective of this study was to generate and test a PD diagnostic criteria termed "clinically established early PD." We modified the Movement Disorder Society criteria to increase specificity for early PD by removing all disease duration components and changing red flags to absolute exclusions. We then estimated the sensitivity/specificity of clinically established early PD criteria in patients with disease duration <5 years, selected from a 626-patient validation study. After documentation of parkinsonism, 18 individual exclusion criteria are assessed that preclude the diagnosis of "clinically established early PD." Among 212 PD and 152 non-PD patients, the estimated specificity was 95.4%, with 69.8% sensitivity. We describe high-specificity criteria for de novo PD, which are freely available for use in clinical trials. © 2018 International Parkinson and Movement Disorder Society.

References

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Mar 13, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaGünther Deuschl
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
May 14, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Gesine RespondekUNKNOWN Movement Disorder Society-Endorsed PSP Study Group
May 27, 2017·Brain : a Journal of Neurology·Seyed-Mohammad FereshtehnejadRonald B Postuma

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Citations

Oct 11, 2019·Annals of Clinical and Translational Neurology·Matilde BongianniGianluigi Zanusso
Oct 30, 2019·Acta Neurologica Scandinavica·Yuki OzakiShu-Ichi Ueno
Dec 14, 2019·Brain : a Journal of Neurology·Matteo BolognaAlfredo Berardelli
Sep 20, 2020·Biomolecules·Loredana LeggioNunzio Iraci
Oct 27, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Anette Schrag
May 23, 2019·Frontiers in Neurology·Nupur Nag, George A Jelinek
Jan 18, 2019·Nature Reviews. Neurology·Günther Deuschl, Rob M A de Bie
Jul 1, 2020·Journal of Parkinson's Disease·Sven R SuwijnRob M A de Bie
Feb 20, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Tanya SimuniUNKNOWN Parkinson's Progression Markers Initiative Investigators
Dec 4, 2020·Parkinsonism & Related Disorders·Beatrice HeimKlaus Seppi
Jul 29, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·R García-RamosJ C Martínez Castrillo
Dec 29, 2020·Frontiers in Aging Neuroscience·Fredric P ManfredssonRonald J Mandel
Nov 14, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·David DevosRichard Wyse
Apr 20, 2021·Frontiers in Human Neuroscience·Abhimanyu MahajanKelly A Mills
Apr 2, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Giulia PaparellaMatteo Bologna
Jun 23, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Sandra H VosVitória Piai
Aug 10, 2021·Journal of Parkinson's Disease·Amber D Van LaarKrystof S Bankiewicz
Aug 24, 2021·Parkinsonism & Related Disorders·Ioanna PachiLeonidas Stefanis
Sep 18, 2021·Molecular Medicine·Sanne K MelesKlaus L Leenders

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