Movement Disorders and Syndromic Autism: A Systematic Review

Journal of Autism and Developmental Disorders
L BellD J Hare

Abstract

Movement disorders are reported in idiopathic autism but the extent to which comparable movement disorders are found in syndromic/co-morbid autism is unknown. A systematic search of Medline, Embase, PsychINFO and CINAHL on the prevalence of specific movement disorder in syndromic autism associated with specific genetic syndromes identified 16 papers, all relating to Angelman syndrome or Rett syndrome. Prevalence rates of 72.7-100% and 25.0-27.3% were reported for ataxia and tremor, respectively, in Angelman syndrome. In Rett syndrome, prevalence rates of 43.6-50% were reported for ataxia and 27.3-48.3% for tremor with additional reports of dystonia, rigidity and pyramidal signs. However, reliable assessment measures were rarely used and recruitment was often not described in sufficient detail.

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Citations

Jul 9, 2020·Neuropsychiatric Disease and Treatment·Regina SalaPaul Whiteley
Apr 23, 2020·Frontiers in Cell and Developmental Biology·Rui XiaoXiaotang Fan
Jul 25, 2020·Journal of Child Neurology·Emma D BurdekinRujuta B Wilson
Apr 1, 2021·Autism Research : Official Journal of the International Society for Autism Research·Lee Chin WongWang-Tso Lee
Sep 3, 2021·Psychiatry and Clinical Neurosciences·Jatinder SinghParamala Santosh
Feb 6, 2022·Journal of Autism and Developmental Disorders·Udayakumar NarasimhanTeena Koshy

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