Movement Disorders Associated With Antipsychotic Medication in People With Schizophrenia: An Overview of Cochrane Reviews and Meta-Analysis

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
Davide MartinoTamara Pringsheim

Abstract

Movement disorders associated with antipsychotic medications are relatively common, stigmatising, and potentially disabling. Their prevalence in people with psychosis who are prescribed second-generation antipsychotics (SGAs) is uncertain, as is their level of recognition by clinicinas. We conducted meta-analyses of randomised controlled trials included in the Cochrane Database of Systematic Reviews on schizophrenia and schizophrenia-like psychoses to estimate the prevalence of new-onset dystonia, akathisia, parkinsonism, and tremor with SGAs (amisulpride, asenapine, aripiprazole, clozapine, olanzapine, paliperidone, quetiapine, risperidone, L-sulpiride, and ziprasidone) approved in Canada and the UK, comparing them with haloperidol and chlorpromazine. We used a random effects model because of the heterogeneity between-studies in drug dosage and method of ascertainment of movement disorders. Our systematic search yielded 37 Cochrane systematic reviews (28 for SGAs), which generated 316 informative randomised controlled trials (243 for SGAs). With respect to SGAs, prevalence estimates ranged from 1.4% (quetiapine) to 15.3% (L-sulpiride) for dystonia, 3.3% (paliperidone) to 16.4% (L-sulpiride) for akathisia, 2.4% (asenapine) to 2...Continue Reading

References

Oct 1, 1983·Archives of General Psychiatry·G A KeepersD E Casey
May 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·N GiladiS Fahn
Apr 3, 2004·Nature Reviews. Drug Discovery·Bryan L RothWesley K Kroeze
Mar 15, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel Tarsy, Ross J Baldessarini
Sep 2, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Michele TinazziAngelo Antonini
Jan 13, 2009·Acta Psychiatrica Scandinavica. Supplementum·P E BebbingtonM Toumi
Jul 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Alison PopeThomas R E Barnes
Nov 30, 2014·Neurologic Clinics·Shyamal H MehtaKapil D Sethi
Jul 20, 2017·Therapeutics and Clinical Risk Management·Marco SolmiAndré F Carvalho
Oct 13, 2017·The Journal of Clinical Psychiatry·Christoph U CorrellLeslie L Citrome
Dec 1, 2017·Neurology. Clinical Practice·Davide Martino, Francesca Morgante

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Citations

Jul 3, 2020·The International Journal of Pharmacy Practice·Leanne TeohGeraldine Moses
Jun 29, 2018·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Tamara Pringsheim, Thomas R E Barnes
Jun 20, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Rosa MolinaEnrique Baca-García
Jun 14, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Leanne TeohMichael John McCullough
Nov 28, 2020·Current Treatment Options in Oncology·Mellar P Davis, Gareth J Sanger
Jul 8, 2019·Lancet Neurology·Stewart A FactorCynthia L Comella
Dec 22, 2020·Behavioural Brain Research·Alice ServonnetAnne-Noël Samaha
Jan 13, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Mario MajJoseph Ventura
Feb 9, 2021·Expert Opinion on Pharmacotherapy·Jessie S Gibson, Daniel O Claassen
Jan 27, 2020·BMJ Neurology Open·Alice PowellMichael William Hayes
Jun 8, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jessica BaumgärtnerSusanne Stübner
Jul 16, 2021·Oncotarget·Pareesa Kamgar-Dayhoff, Tinatin I Brelidze
Oct 16, 2021·Clinical Neuropharmacology·Henrique Castro SantosJoana Pereira

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Methods Mentioned

BETA
SGA

Software Mentioned

Comprehensive Meta - Analysis

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