PMID: 6406409Apr 1, 1983Paper

Movement of CO2 and HCO-3 from blood to brain in dogs

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
D C JohnsonH Kazemi

Abstract

The ratio of carbon dioxide (CO2) to bicarbonate (HCO-3) is important in acid-base homeostasis and to the central chemical drive to ventilation. The entry of HCO-3 from blood into the central nervous system (CNS) has been controversial, and the entry of CO2, assumed to be rapid, has not been separated from HCO-3 entry. Therefore the rates of movement of CO2 and of HCO-3 from blood to CNS were evaluated. The first-pass brain uptake of 11C-labeled CO2-HCO-3 was studied under conditions with and without carbonic anhydrase inhibition (CAI), with the isotope injected either as CO2 (acid injectate) or as HCO-3 (alkaline injectate) into the aortic arch of anesthetized dogs. The uptake of 11C under conditions without CAI was about 80% and remained the same whether the isotope was injected as CO2 or as HCO-3. The uptake of 11C under conditions of cerebroventricular administration of acetazolamide was 61.5 +/- 2.0% after injection as CO2 and 56.7 +/- 8.3% after injection as HCO-3. The uptake of 11C under conditions of systemic CAI was 50.3 +/- 3.0% after injection as CO2 and 19.3 +/- 1.1% after injection as HCO-3. The uptakes were comparable for the combination of cerebroventricular and intravenous acetazolamide. From the values for 11C ...Continue Reading

Citations

Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B BuxtonR H Ackerman
Mar 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B BuxtonJ A Correia
Jan 6, 2017·Physiological Reports·Henriette L ChristensenJeppe Praetorius

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