Movement-related discharge in the macaque globus pallidus during high-frequency stimulation of the subthalamic nucleus

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Andrew J ZimnikR S Turner

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) has largely replaced ablative therapies for Parkinson's disease. Because of the similar efficacies of the two treatments, it has been proposed that DBS acts by creating an "informational lesion," whereby pathologic neuronal firing patterns are replaced by low-entropy, stimulus-entrained firing patterns. The informational lesion hypothesis, in its current form, states that DBS blocks the transmission of all information from the basal ganglia, including both pathologic firing patterns and normal, task-related modulations in activity. We tested this prediction in two healthy rhesus macaques by recording single-unit spiking activity from the globus pallidus (232 neurons) while the animals completed choice reaction time reaching movements with and without STN-DBS. Despite strong effects of DBS on the activity of most pallidal cells, reach-related modulations in firing rate were equally prevalent in the DBS-on and DBS-off states. This remained true even when the analysis was restricted to cells affected significantly by DBS. In addition, the overall form and timing of perimovement modulations in firing rate were preserved between DBS-on and DBS-off states in the majori...Continue Reading

Citations

Oct 16, 2015·Neurologia Medico-chirurgica·Anand Tekriwal, Gordon Baltuch
Mar 10, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas Wichmann, Mahlon R DeLong
Oct 5, 2015·Parkinsonism & Related Disorders·Alan D DorvalJerrold L Vitek
Dec 14, 2017·Brain : a Journal of Neurology·Luka MilosevicWilliam D Hutchison
Apr 26, 2017·Frontiers in Neural Circuits·Quanchao ZhangXiaowei Chen
Dec 14, 2019·Neurosurgery·Josue M Avecillas-Chasin, Christopher R Honey
Jan 27, 2019·Nature Reviews. Neurology·Andres M LozanoJoachim K Krauss
Dec 1, 2018·Bioelectronics in Medicine·Xiaoyu PengCristin G Welle
Apr 30, 2021·The European Journal of Neuroscience·Mohammadreza Mohagheghi NejadRobert Schmidt

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