Movement-related discharge of ventromedial medullary neurons

Journal of Neurophysiology
H Foo, Peggy Mason

Abstract

Studies in anesthetized animals implicate nonserotonergic cells in the ventromedial medulla (VMM) in opioid modulation of nociceptive transmission but do not reveal the conditions that engage VMM cells in unanesthetized rats. The few studies of VMM cells in unanesthetized rats show that VMM cells change their discharge across the sleep-wake cycle and during active movements. Since active movements are more likely to occur during waking than sleep, state-related discharge may in fact represent movement-related discharge. In this study, we recorded the discharge of VMM neurons in unanesthetized, drug-free, freely moving rats and examined whether neuronal activity was related to wake/sleep state, to motor activity, or to both factors. Most cells (45/67) were more active during waking states than sleeping states, 1 cell was more active during sleep states, and the remaining 21 cells did not fire preferentially across the sleep-wake cycle. Most wake-active cells (36/45) showed discharge bursts during movement bursts, and 9/11 wake-active cells were excited by noxious heat and innocuous air puff stimulation. In contrast, few state-independent cells (9/21) showed movement-related bursts in discharge. These results suggest that VMM neu...Continue Reading

References

May 13, 1977·Brain Research·H L FieldsS D Anderson
Nov 1, 1976·Experimental Neurology·G M MoolenaarC O Trouth
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A I BasbaumH L Fields
Nov 21, 1975·Brain Research·H K Proudfit, E G Anderson
May 11, 1991·The Journal of Comparative Neurology·R L MassonL A Ritz
Jul 1, 1991·Physiology & Behavior·J N van BetterayA M Coenen
Mar 1, 1990·Brain Research Bulletin·N KinjoE Garcia-Rill
Jan 1, 1989·Progress in Brain Research·A RoucouxM F Decostre
Jun 20, 1974·Brain Research·Y S SheuF E Bloom
Oct 1, 1994·Journal of Neurophysiology·D B ThomsonF J Richmond
Jan 1, 1994·Progress in Brain Research·A K Asbury
Jan 1, 1993·Experimental Brain Research·V C AbrahamsS A Keirstead
Feb 26, 1999·Journal of Neurophysiology·C G Leung, P Mason
Apr 27, 2002·Journal of Neurophysiology·Boris Y MileykovskiyJerome M Siegel
Feb 19, 2003·Brain Research. Brain Research Reviews·Barry L JacobsCasimir A Fornal
Feb 20, 2004·Journal of Neurophysiology·Malcolm W Nason, Peggy Mason

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Citations

Nov 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·H Foo, Peggy Mason
Jul 4, 2018·Cephalalgia : an International Journal of Headache·Marta Vila-PueyoSimon Akerman
Sep 21, 2011·Nature Reviews. Neuroscience·Simon AkermanPeter J Goadsby

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