Movement-related potential measures of different modes of movement selection in Parkinson's disease

Journal of the Neurological Sciences
P PraamstraM W Horstink

Abstract

Movement-related potentials were recorded preceding self-paced voluntary movements in patients with Parkinson's disease and in healthy subjects of the same age group. We compared the Readiness Potential preceding joystick movements in a fixed direction and preceding joystick movements in freely selected directions. In normal subjects the Readiness Potential amplitude was higher preceding freely selected movements than preceding movements in a fixed direction. The Readiness Potential in Parkinson patients failed to be modified by the different modes of movement selection. The modulation of the Readiness Potential by different ways of preparing for movement might be due to the supplementary motor area (SMA) being more strongly engaged by tasks requiring internal control of movements than by tasks that are externally structured. The results suggest that this task-dependent variation of SMA activity is reduced in Parkinson's disease. A failing capacity to adapt SMA activity to different task demands has previously been suggested by evidence from positron emission tomography studies using similar tasks.

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Citations

Apr 22, 1999·Annals of Neurology·R G BrownJ C Rothwell
Jun 1, 1996·Electroencephalography and Clinical Neurophysiology·P PraamstraA R Cools
Feb 15, 2002·Brain : a Journal of Neurology·James RoweRichard Passingham
Jan 24, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Ana BujánFernando Díaz
Jan 11, 2008·The European Journal of Neuroscience·Annette Sterr, Philip Dean
Aug 1, 2014·Journal of Neurophysiology·Julià L AmengualAntoni Rodríguez-Fornells
Aug 17, 2017·Arquivos de neuro-psiquiatria·Isabella Araújo MotaOtávio Gomes Lins
Jul 14, 2020·Experimental Brain Research·Shiro TakashimaRenato T Ramos

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