PMID: 8945745Nov 1, 1996Paper

Movements of mouse fetuses in early stages of neural development studied in vitro

Neuroscience Letters
T Suzue

Abstract

The transplacental perfusion method enables the in vitro maintenance and close observation of live mouse fetuses under conditions free of maternal influences. In the present study, this method was used to detect spontaneous movements of mouse fetuses in early developmental stages. When mouse fetuses at embryonic day (E) 12.5 were isolated together with the uterus and were maintained in vitro, they displayed periodic body movements that occurred every few minutes. Fetal movements were abolished after the application of drugs that depress neural activities. The present results obtained in in vitro mouse fetuses suggest that fetal movements and neural activities may be present during the early stages of motor system development and may play a role in the normal maturation of the motor systems.

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Citations

Apr 21, 2011·Biomechanics and Modeling in Mechanobiology·Niamh C NowlanPaula Murphy
Apr 12, 2005·Cell Calcium·Michael J O'DonovanGeorge Z Mentis
Aug 21, 2013·Differentiation; Research in Biological Diversity·Yulia ShwartzElazar Zelzer
Feb 19, 2003·Brain Research. Brain Research Reviews·Agnès BonnotMichael J O'Donovan
Dec 23, 1999·Current Opinion in Neurobiology·M Bate
Oct 18, 2008·Development·Sarah CrispMichael Bate
May 1, 2007·Journal of Neurosurgery·Dorothea StiefelMartin Meuli
Mar 28, 2008·Journal of Neuroscience Methods·Elaine M StockxPhilip J Berger
Jul 14, 2007·Journal of Physiology, Paris·C BordayG Fortin
Mar 15, 2006·Respiratory Physiology & Neurobiology·F ChatonnetJ Champagnat
May 23, 2009·Developmental Cell·Joy KahnElazar Zelzer
Apr 15, 2008·Journal of Pediatric Surgery·Dorothea Stiefel, Martin Meuli
Dec 1, 2017·Development·Neta Felsenthal, Elazar Zelzer
Jun 12, 2010·Organogenesis·Jean-François Colas, James Sharpe
Aug 2, 2017·Journal of Anatomy·Alexander SpassovKornelius Kupczik
May 28, 2020·Disease Models & Mechanisms·Sukalp MuzumdarMatthias Schäfer

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