Moving beyond the "LDL hypothesis"

VASA. Zeitschrift für Gefässkrankheiten
Christian Werner, Ulrich Laufs

Abstract

The term "LDL hypothesis" is frequently used to describe the association of low-density lipoprotein cholesterol (LDL-cholesterol, LDL-C) and cardiovascular (CV) events. Recent data from genetic studies prove a causal relation between serum LDL-C and CV events. These data are in agreement with mechanistic molecular studies and epidemiology. New randomised clinical trial data show that LDL-C lowering with statins and a non-statin drug, ezetimibe, reduces CV events. We therefore believe that the "LDL-hypothesis" has been proven; the term appears to be outdated and should be replaced by "LDL causality".

Citations

Oct 23, 2016·Wiener medizinische Wochenschrift·Raimund WeitgasserPeter Siostrzonek
Jan 27, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Handrean SoranPaul Durrington
Jan 7, 2017·Circulation Research·Adam OesterleJames K Liao

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