Moving forward: distinct sensorimotor abnormalities predict clinical outcome after 6 months in patients with schizophrenia.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Fabio SambataroDusan Hirjak

Abstract

Despite substantial efforts in the last decades, objective measures that can predict clinical outcome in patients with schizophrenia (SZ) after an acute psychotic episode are still lacking. Here, we introduced a comprehensive assessment of sensorimotor function to predict mid-term clinical outcome following an acute psychotic episode. This naturalistic follow-up of 43 patients with DSM-IV-TR diagnosis of SZ examined sensorimotor abnormalities (i.e. Neurological Soft Signs (NSS), parkinsonism, akathisia, catatonia and acute dyskinesia), psychopathology, cognition and psychosocial functioning using well-established instruments. A collection of statistical methods was used to examine the relationship between sensorimotor domain, psychopathology, cognition and psychosocial functioning. We also tested the clinical feasibility of this relationship when predicting clinical outcome after an acute psychotic episode. Longitudinal data were collected on 43 individuals after a follow-up period of >6 months. At follow-up, patients showed significantly reduced general symptom severity, as well as decreased levels of NSS, parkinsonism and catatonia. Further, NSS scores at baseline predicted PANSS negative scores and cognitive functioning at b...Continue Reading

Citations

Jan 26, 2021·Frontiers in Psychology·Anastasia Pavlidou, Sebastian Walther
Jun 5, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dusan HirjakRobert C Wolf
Jun 12, 2021·Der Nervenarzt·Dusan HirjakRobert Christian Wolf

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