Moving forward toward standardizing analysis of quality of life data in randomized cancer clinical trials

Clinical Trials : Journal of the Society for Clinical Trials
A BottomleyCorneel Coens

Abstract

There is currently a lack of consensus on how health-related quality of life and other patient-reported outcome measures in cancer randomized clinical trials are analyzed and interpreted. This makes it difficult to compare results across randomized controlled trials (RCTs) synthesize scientific research, and use that evidence to inform product labeling, clinical guidelines, and health policy. The Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints Data for Cancer Clinical Trials (SISAQOL) Consortium aims to develop guidelines and recommendations to standardize analyses of patient-reported outcome data in cancer RCTs. Members from the SISAQOL Consortium met in January 2017 to discuss relevant issues. Data from systematic reviews of the current state of published research in patient-reported outcomes in cancer RCTs indicated a lack of clear reporting of research hypothesis and analytic strategies, and inconsistency in definitions of terms, including "missing data,"health-related quality of life," and "patient-reported outcome." Based on the meeting proceedings, the Consortium will focus on three key priorities in the coming year: developing a taxonomy of research objectives, identi...Continue Reading

References

Nov 27, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Michael BrundageDeb Feldman-Stewart
Mar 2, 2012·The New England Journal of Medicine·Michael J Barry, Susan Edgman-Levitan
Oct 5, 2012·The New England Journal of Medicine·Roderick J LittleHal Stern
Feb 28, 2013·JAMA : the Journal of the American Medical Association·Melanie CalvertUNKNOWN CONSORT PRO Group
Mar 24, 2015·Lancet·Melanie CalvertDavid Moher
Jan 30, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ines RombachÓrlaith Burke
Sep 22, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·S FieldingC R Ramsay
Oct 8, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Agnes V KleinDeborah A Marshall
Oct 23, 2016·The Lancet Oncology·Andrew BottomleyUNKNOWN Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints Data (SISAQOL) consorti

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Citations

Jan 19, 2019·British Journal of Haematology·Lene Kongsgaard NielsenTobias Wirenfeld Klausen
Apr 9, 2019·Journal of the National Cancer Institute·Ethan Basch, Allison Barz Leahy
Nov 14, 2019·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Bonnie AddarioNicole Willmarth
Feb 23, 2020·European Journal of Haematology·Emma Bergfelt LennmyrHeléne Hallböök
Mar 11, 2020·Clinical Trials : Journal of the Society for Clinical Trials·Jessica K RoydhousePaul G Kluetz
Aug 19, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Caroline Bascoul-MolleviAmélie Anota
Sep 14, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·S DeschuymerS Nuyts
Apr 23, 2019·The Journal of Clinical Endocrinology and Metabolism·Emily KrantzUlla Wide
Oct 14, 2020·Health and Quality of Life Outcomes·Parisa Mokhatri-Hesari, Ali Montazeri
Feb 23, 2021·Gynecologic Oncology·Jean-Emmanuel KurtzUNKNOWN Gynecologic Cancer InterGroup (GCIG) symptom benefit committee
Apr 3, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Michael J PalmerMichael Brundage
May 13, 2021·Best Practice & Research. Clinical Gastroenterology·Kerstin SchütteKristina Middelberg-Bisping
Feb 3, 2020·The Lancet Oncology·Corneel CoensUNKNOWN Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints Data Consortium

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SISAQOL

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