Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: A NCI clinical trials planning meeting report

Gynecologic Oncology
Stephanie LheureuxElise C Kohn

Abstract

The incidence of endometrial cancer (EC) in the U.S. has been rising, from an estimated annual incidence of 49,560 in 2013 to 61,380 in 2017. Meanwhile, the SEER-based relative survival of women with EC in the U.S. has remained flat [82.3% from 1987 to 1989, 82.8% from 2007 to 2013] and our recent increased understanding of EC biology and subtypes has not been translated into therapeutic advances. The U.S. National Cancer Institute (NCI) therefore convened a Uterine Clinical Trials Planning Meeting in January 2016 to initiate and accelerate design of molecularly-targeted EC trials. Prior to the meeting a group of experts in this field summarized available data, emphasizing data on human samples, to identify potentially actionable alterations in EC, and the results of their work has been separately published. The Clinical Trials Meeting planners focused on discussion of (1) novel trial designs, including window-of opportunity trials and appropriate control groups for randomized trials, (2) targets specific to serous carcinoma and promises and pitfalls of separate trials for women with tumors of this histology (3) specific recommendations for future randomized trials.

Citations

Nov 14, 2018·Japanese Journal of Clinical Oncology·Takashi MitamuraHidemichi Watari
May 11, 2019·CA: a Cancer Journal for Clinicians·Rebecca A BrooksJennifer L Veneris
Feb 19, 2020·Current Oncology Reports·Michelle LightfootKristin Bixel
Aug 15, 2018·International Journal of Molecular Sciences·Michiel Remmerie, Veerle Janssens
Jun 20, 2019·Frontiers in Oncology·Michiel Remmerie, Veerle Janssens
Mar 27, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda R DuskaKimberly K Leslie
May 27, 2021·BioMed Research International·Suk-Young Lee

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