Moving targets in drug discovery

Scientific Reports
Barbara ZdrazilRajarshi Guha

Abstract

Drug Discovery is a lengthy and costly process and has faced a period of declining productivity within the last two decades resulting in increasing importance of integrative data-driven approaches. In this paper, data mining and integration is leveraged to inspect target innovation trends in drug discovery. The study highlights protein families and classes that have received more attention and those that have just emerged in the scientific literature, thus highlighting novel opportunities for drug intervention. In order to delineate the evolution of target-driven research interest from a biological perspective, trends in biological process annotations from Gene Ontology and disease annotations from DisGeNET are captured. The analysis reveals an increasing interest in targets related to immune system processes, and a recurrent trend for targets involved in circulatory system processes. At the level of diseases, targets associated with cancer-related pathologies, intellectual disability, and schizophrenia are increasingly investigated in recent years. The methodology enables researchers to capture trends in research attention in target space at an early stage during the drug discovery process. Workflows, scripts, and data used in...Continue Reading

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Citations

Mar 18, 2021·Journal of Chemical Information and Modeling·Norberto Sánchez-Cruz, José L Medina-Franco
Mar 27, 2021·Journal of Medicinal Chemistry·Norberto Sánchez-Cruz, José L Medina-Franco
Aug 5, 2021·Scientific Reports·Guillermo Serrano NájeraDaniel J Crowther

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Software Mentioned

DisGeNET
Resolute
PubMed
pgAdmin4
MoA
R
PostgreSQL
MASS
KNIME
sfsmisc

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