Moving to the suburbs: T-cell positioning within lymph nodes during activation and memory

Immunology and Cell Biology
Joanna R Groom

Abstract

Lymph nodes are highly organized secondary lymphoid structures crucial for the initiation of immune responses. Naive T cells are strategically located within lymph nodes to optimize their encounter with antigen-loaded dendritic cells. Recent advances in 3D lymph node imaging and tissue reconstruction along with methods for the detection of chemokine expression and gradients have highlighted how T cells position themselves during activation and memory responses. This article covers new insights into the guidance mechanisms that co-ordinate T-cell responses within draining lymph nodes. Furthering our understanding of how these pathways are regulated and promoted will lead to the exploitation of T-cell positioning to further strategize vaccine design.

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Citations

Apr 22, 2015·Immunology and Cell Biology·Joanna R Groom
Mar 30, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yujia LinShan Liao
Oct 25, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali SepahiIrene Salinas
Aug 30, 2017·The Journal of Experimental Medicine·Michael Y GernerRonald N Germain
Oct 2, 2020·Cellular & Molecular Immunology·Amania A Sheikh, Joanna R Groom
Feb 16, 2021·Immunological Reviews·Brigette C Duckworth, Joanna R Groom
Feb 21, 2018·Trends in Cancer·Mansi Saxena, Nina Bhardwaj

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