MOXE: a model of gas exchange for hyperpolarized 129Xe magnetic resonance of the lung

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Yulin V Chang

Abstract

We present a model of gas exchange for hyperpolarized (129)Xe in the lung, which we refer to as the Model of Xenon Exchange. The model consists of two expressions and characterizes uptake of dissolved xenon in the lung at two different resonance frequencies. The two expressions are governed by the following five critical pulmonary parameters that characterize both lung function and structure: the surface-area-to-volume ratio, barrier-to-septum ratio (ratio between air-blood barrier thickness and septal thickness), hematocrit, gas-exchange time constant, and pulmonary capillary transit time. The model is first validated by computer simulation. We show that Model of Xenon Exchange can be used to measure the pulmonary parameters mentioned above under various pathological or physiological conditions and is robust against moderate noise. Model of Xenon Exchange is further used to fit an existing data set of xenon uptake, thereby we demonstrate that the data can be well interpreted with Model of Xenon Exchange and reasonable parameters from the fitting routine. The good results obtained in both simulation and fitting to real data indicate that the model is sensitive to various functional and structural changes of the lung, and that i...Continue Reading

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Citations

Dec 18, 2015·NMR in Biomedicine·Dmitriy A YablonskiyJames D Quirk
Aug 16, 2016·Journal of Magnetic Resonance·Neil J StewartJim M Wild
May 29, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai RuppertJohn P Mugler
Apr 24, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai RuppertRahim R Rizi
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew S FreemanBastiaan Driehuys
Sep 25, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Haidong LiXin Zhou
Aug 30, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Graham NorquayJim M Wild
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May 13, 2014·NMR in Biomedicine·Zackary I ClevelandBastiaan Driehuys
Oct 23, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai RuppertRahim R Rizi
Oct 27, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Agilo L KernJens Vogel-Claussen
Apr 17, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Brandon Zanette, Giles Santyr
May 18, 2013·Journal of Magnetic Resonance Imaging : JMRI·Kun QingJohn P Mugler
Oct 25, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yulin V ChangJason C Woods
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