Moxibustion relieves visceral hyperalgesia via inhibition of transient receptor potential vanilloid 1 (TRPV1) and heat shock protein (HSP) 70 expression in rat bone marrow cells

Acupuncture in Medicine : Journal of the British Medical Acupuncture Society
Weiying ZouDalei Zhang

Abstract

To investigate the effects of moxibustion on visceral hyperalgesia (VH) and bone marrow cell transient receptor potential vanilloid type 1 (TRPV1) and heat shock protein (HSP) 70 expression in a rat model of VH. Mechanical colorectal distension was performed to induce VH in neonatal Sprague-Dawley rats. Eight-week-old VH rats were treated with moxibustion at acupuncture point BL25 or an ipsilateral non-acupuncture point. Abdominal withdrawal reflex (AWR) scoring and pain threshold pressure assessment were performed before and after moxibustion treatment for 7 consecutive days. The expression of TRPV1 and HSP70 in bone marrow cells was quantified by real-time quantitative PCR. The expression of TRPV1 and HSP70 in bone marrow cells was increased in rats with VH. Moxibustion at BL25 significantly decreased AWR scores and increased pain threshold pressure in rats with VH. Furthermore, moxibustion at BL25 significantly inhibited the VH-induced increase in the expression of TRPV1 and HSP70 in bone marrow cells. The up-regulation of TRPV1 and HSP70 expression in bone marrow cells may be involved in visceral pain development and the analgesic effect of moxibustion on VH may be mediated through down-regulation of TRPV1 and HSP70 express...Continue Reading

References

Jan 1, 1995·The American Journal of Chinese Medicine·K Kobayashi
May 15, 2010·European Journal of Immunology·Taoyong Chen, Xuetao Cao
Nov 9, 2010·BMC Research Notes·Myeong Soo LeeEdzard Ernst
Jan 25, 2011·Journal of Chemical Neuroanatomy·Therese S AbrahamSheng-Xing Ma
Apr 5, 2011·European Journal of Cell Biology·Anna JoleschElfriede Noessner
Apr 19, 2012·International Journal of Sports Medicine·J LuJ-Y Guo
Aug 11, 2012·Behaviour Research and Therapy·Kate Wolitzky-TaylorBruce D Naliboff
Oct 27, 2012·European Journal of Pharmacology·Wim VermeulenBenedicte Y De Winter
Apr 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Li QiHuan-Gan Wu
Apr 23, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jen-Hwey Chiu
Jul 25, 2013·Frontiers in Immunology·Laura G Schuettpelz, Daniel C Link
Aug 13, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Gui-Ying WangJin-Feng Jiang
Oct 4, 2013·BMC Complementary and Alternative Medicine·Jae-Woo ParkHyangsook Lee
Mar 7, 2014·Molecular Immunology·Joakim S Dahlin, Jenny Hallgren
May 7, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M BashashatiM Simrén

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Citations

May 4, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xianwei ZhuJing Zhou
Jun 24, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Marilena Gilca, Dorin Dragos
Jun 13, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jingjing XuJiyang Dong
Sep 23, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Huaijin ChengXueyong Shen
Jun 13, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Qin QiXiaomei Wang
Sep 14, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Hsin-Cheng HsuYi-Wen Lin
Feb 23, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Kyung Ho HwangYong Ju Kim

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