Moxifloxacin and glucose homeostasis: a pooled-analysis of the evidence from clinical and postmarketing studies

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
James R GavinJutta M Meyer

Abstract

Recently, clinical data has emerged suggesting that the fluoroquinolone, gatifloxacin, can affect glucose homeostosis through an unknown mechanism. In order to explore the potential effects of moxifloxacin on glucose metabolism in humans, a pooled analysis of phase II/III clinical trials and postmarketing studies was performed and compared with results from an investigation in laboratory animals. A pooled analysis of 30 (26 controlled, 4 uncontrolled) oral and two intravenous/oral prospective, controlled phase II/III moxifloxacin studies was performed to evaluate the frequency of hyper- and hypoglycaemic episodes and glucose-related adverse events and adverse reactions (i.e. those considered to be drug related) versus comparator antimicrobials (penicillins, cephalosporins, macrolides, doxycycline, fluoroquinolones). Similar evaluations were conducted on data pooled from five postmarketing surveillance studies. In addition, potential effects of supratherapeutic doses of moxifloxacin on blood glucose and plasma insulin levels in fed and fasted rats were assessed in comparison with those of gatifloxacin, levofloxacin and glibenclamide (glyburide). The phase II/III database was comprised of 14,731 patients (8474 moxifloxacin, 6257 ...Continue Reading

References

Apr 1, 1993·Annals of Internal Medicine·M K PanditA N Peiris
Aug 1, 1996·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J C ChanJ A Critchley
Sep 29, 1999·Endocrinology and Metabolism Clinics of North America·V Marks, J D Teale
Mar 27, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P B IanniniG Tillotson
Jul 4, 2001·JPEN. Journal of Parenteral and Enteral Nutrition·B R Bistrian
Nov 3, 2001·JAMA : the Journal of the American Medical Association·B Luna, M N Feinglos
Oct 26, 2002·The Annals of Pharmacotherapy·Stacey E Baker, Matthew C Hangii

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Citations

Feb 26, 2008·Pharmacy World & Science : PWS·Ahunna J OnyenwenyiRandy C Hatton
May 2, 2009·American Journal of Respiratory and Critical Care Medicine·Susan E DormanUNKNOWN Tuberculosis Trials Consortium
Apr 20, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Hans H Liu
Aug 1, 2008·Expert Review of Respiratory Medicine·Hartmut M Lode, Malina Schmidt-Ioanas
Dec 13, 2006·Treatments in Respiratory Medicine·George G ZhanelDaryl J Hoban
Jun 15, 2007·Current Medical Research and Opinion·Paul B Iannini
Jun 9, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C Owens, Paul G Ambrose
Mar 25, 2008·Therapeutics and Clinical Risk Management·David Rp Guay
Apr 28, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Vincent T AndrioleShurjeel H Choudhri
Nov 18, 2010·Drugs·Ann M Ginsberg
Jun 23, 2006·The New England Journal of Medicine·Karl P Ittner
Jun 4, 2010·Critical Care Medicine·Zachariah ThomasAtul Malhotra
Mar 9, 2011·Journal of Clinical Pharmacology·Rajan KapoorStephen Jesmajian
Aug 18, 2009·Expert Review of Anti-infective Therapy·Olaf Burkhardt, Tobias Welte

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