Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine.

Antimicrobial Agents and Chemotherapy
Simbarashe P ZvadaH McIlleron

Abstract

We described the population pharmacokinetics of moxifloxacin and the effect of high-dose intermittent rifapentine in patients with pulmonary tuberculosis who were randomized to a continuation-phase regimen of 400 mg moxifloxacin and 900 mg rifapentine twice weekly or 400 mg moxifloxacin and 1,200 mg rifapentine once weekly. A two-compartment model with transit absorption best described moxifloxacin pharmacokinetics. Although rifapentine increased the clearance of moxifloxacin by 8% during antituberculosis treatment compared to that after treatment completion without rifapentine, it did not result in a clinically significant change in moxifloxacin exposure.

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Citations

Jan 9, 2013·Antimicrobial Agents and Chemotherapy·Giovanni PiccaroLanfranco Fattorini
Oct 23, 2014·The New England Journal of Medicine·Amina JindaniUNKNOWN RIFAQUIN Trial Team
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Aug 15, 2017·Expert Review of Clinical Pharmacology·Omamah AlfarisiCharles A Peloquin
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Nov 19, 2020·European Journal of Clinical Pharmacology·Roeland E WasmannRob Ter Heine
Jul 22, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kendra K RadtkeAnthony J Garcia-Prats

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