Moyamoya disorder in the United States

Robert M StarkeAaron S Dumont


In Asian populations, moyamoya disease has a well-defined phenotype including a bimodal age of presentation with children typically presenting with ischemic phenomena and adults presenting with hemorrhage. Studies have provided evidence that moyamoya disease in the United States may exhibit a different phenotype. To assess overall rates of admission, demographics, procedures, and outcomes of patients admitted or diagnosed with moyamoya disorder in US hospitals. A comprehensive assessment of the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project (2002-2008) was performed. Patient demographics, comorbidities, procedures, and outcomes were analyzed. There were 2280 admissions for moyamoya disorder with a predicted national estimate of 11 163 admissions (0.57/100 000 persons/y). Over time, there was a significant increase in diagnosis and associated ischemic strokes. Females (72%) were affected more than males (28%). Demographics included white (49%), black (24%), Hispanic (11%), Asian (11%), and other (3.3%). Mean age at presentation was 31.6 ± 18.0. Children were significantly more likely to be diagnosed with ischemic phenomena (16.4%) than hemorrhage (3.3%), as were adults (18.8% vs 11.0%). Status at disc...Continue Reading


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