Abstract
MOZ-TIF2 and MOZ-CBP are leukemogenic fusion proteins associated with therapy-induced acute myeloid leukemia. These proteins are thought to subvert normal gene expression in differentiating hematopoietic progenitor cells. We have previously shown that MOZ-TIF2 inhibits transcription by CREB-binding protein (CBP)/p300-dependent activators such as nuclear receptors and p53. Here we have shown that MOZ-TIF2 associates with the RARbeta2 promoter in vivo, resulting in altered recruitment of CBP/p300, aberrant histone modification, and down-regulation of the RARbeta2 gene. In contrast, MOZ-TIF2 up-regulated transcription mediated by the MOZ/MYST3-dependent activator AML1/RUNX1. Both wild type MOZ and MOZ-TIF2 were found to colocalize with AML1, and MOZ-TIF2 was recruited to an AML1 target promoter. A MOZ-CBP fusion protein showed similar functions to MOZ-TIF2 in that it inhibited retinoic acid receptor-mediated transcription but enhanced AML1 reporter activation. Although it contains almost the entire CBP sequence, MOZ-CBP does not appear to associate with PML bodies. In summary, our results indicate that leukemogenic MOZ fusion proteins have differential effects on the activities of CBP-dependent and MOZ-dependent activators because...Continue Reading
References
Jan 26, 1996·Cell·T OkudaJ R Downing
Sep 1, 1996·Nature Genetics·J BorrowD E Housman
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·K SasakiT Komori
Sep 25, 1999·The Journal of Biological Chemistry·N ChampagneX J Yang
Dec 22, 1999·Biochemical and Biophysical Research Communications·S Takechi, T Nakayama
Jul 6, 2000·Molecular Cell·A Akhtar, P B Becker
Mar 22, 2001·EMBO Reports·A Akhtar, P B Becker
Apr 21, 2001·Oncogene·N ChampagneX J Yang
Oct 3, 2001·Genes & Development·T YahataT Shioda
Dec 18, 2001·The EMBO Journal·I KitabayashiM Ohki
Dec 26, 2001·EMBO Reports·Uta-Maria BauerTony Kouzarides
Aug 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sailesh SurapureddiJanardan K Reddy
Apr 5, 2003·Cancer Cell·Kenji DeguchiD Gary Gilliland
May 29, 2003·Nucleic Acids Research·Claire A P Bristow, Paul Shore
Oct 17, 2003·The Journal of Biological Chemistry·Bruce A HugMitchell A Lazar
Dec 17, 2003·Cell·Raphaël MétivierFrank Gannon
May 7, 2004·Development·Craig T MillerCharles B Kimmel
Dec 21, 2004·Cancer Cell·Brian J P HuntlyD Gary Gilliland
Jan 20, 2005·Molecular and Cellular Biology·Karin B KindleDavid M Heery
Apr 6, 2005·Molecular Cell·Rushad PavriDanny Reinberg
Jun 16, 2005·Nature Reviews. Molecular Cell Biology·Valentina Perissi, Michael G Rosenfeld
Jul 1, 2005·Nature·David B SeligsonSiavash K Kurdistani
Jan 3, 2006·Molecular Cell·Yannick DoyonJacques Côté
Citations
May 21, 2010·Leukemia·K B KindleD M Heery
Aug 19, 2007·Oncogene·N Avvakumov, J Côté
Aug 19, 2007·Oncogene·X-J Yang, M Ullah
Aug 27, 2013·Nucleic Acids Research·Chun Ming ChanDavid M Heery
May 13, 2008·Development·Kathrin LaueMatthias Hammerschmidt
Oct 24, 2013·Nucleic Acids Research·Ingrid DrevenyDavid M Heery
Dec 3, 2015·Nucleic Acids Research·Brianna J KleinTatiana G Kutateladze
Feb 9, 2016·Experimental Hematology·Anne LargeotGeorges Lacaud
Jan 22, 2014·Genes, Chromosomes & Cancer·Yoshiaki ChinenMasafumi Taniwaki
Jun 16, 2015·Frontiers in Oncology·Xiao-Jian SunLan Wang
Apr 2, 2013·Biochimica Et Biophysica Acta·Shu-Ting LiuShih-Ming Huang
Nov 20, 2009·Developmental Cell·Anne K VossTim Thomas
Dec 17, 2009·Biochemical and Biophysical Research Communications·Colm M RyanDavid M Heery
Nov 29, 2016·Oncogene·L YuK Li
Jun 23, 2016·Oncotarget·Elisabetta FrattaRiccardo Dolcetti
Feb 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine StrehlShai Izraeli
Oct 9, 2021·Blood·Hila FishmanShai Izraeli