MP84 expression in the urine specimens of acute rejection renal transplant recipients

Renal Failure
A Mukhtar

Abstract

MP84 is a novel protein synthesized in response to all cytokines. This antigen is expressed only in stimulated mesangial cells and decreased kidney sections, but not in the normal kidney sections (1,2). This study was performed to determine the excretion of MP84 in the urine of renal transplant recipients with acute rejection. Six persons with renal transplant acute rejection and 10 healthy persons were included. Two urine specimens from each person were collected. Dot-blot assay was performed. It was shown that 12 urine specimens from 6 persons with acute rejection revealed MP84 in the matrix dot-blot assay while there was no staining for MP84 in the urine specimens of healthy persons. This could be due to the immunological alteration during the acute rejection which could lead to autocrine and paracrine secretion of growth factors and then the excretion of MP84 in the urine. The mechanism of MP84 secretion is not clear.

References

Mar 1, 1992·Kidney International·J R SedorM Konieczkowski
Sep 1, 1988·Kidney International·W A Border

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Minerva urologica e nefrologica = The Italian journal of urology and nephrology
A Mukhta, A Darwish
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
H P VerschuurG E Staal
© 2021 Meta ULC. All rights reserved