MPA-modified CdTe quantum dots increased interleukin-1beta secretion through MyD88-dependent Toll-like receptor pathway and NLRP3 inflammasome activation in microglia

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Tianshu WuMeng Tang

Abstract

The excellent optical properties of CdTe quantum dots (QDs) make researchers realize their value on the application of biomedicine, especially neuroscience, as an advanced fluorescent probe. Thus, it is important to evaluate the biosafety of CdTe QDs on the central nervous system (CNS). Our previous studies have conducted a systematic biosafety evaluation of CdTe QDs on the CNS and found several toxic endpoints, one of which is the inflammation on the rat hippocampus, but their underlying mechanism remains unclear. In this study, when BV2 microglial cells were exposed to CdTe QDs with doses <20 nM, there was no obviously adverse effect. However, 40 nM CdTe QDs exposure could significantly activate the BV2 cells and increase the pro-inflammatory cytokine IL-1ß secretion. Molecular biology analyses suggested that both TLR2/MyD88/NF-κB pathway and NLRP3 inflammasome participated in the CdTe QD-induced IL-1ß secretion. The former served as the first signal for pro-IL-1ß expression, while the later played a role on the maturation of pro-IL-1ß into IL-1ß. The results, taken together, demonstrated that MPA-modified CdTe QDs exposure with a high concentration was capable of activating microglial cells and promoting IL-1ß secretion, whi...Continue Reading

Citations

Dec 5, 2018·Journal of Applied Toxicology : JAT·Keyu HeMeng Tang
May 23, 2020·International Journal of Nanomedicine·Tianshu WuMeng Tang
Jul 12, 2019·Journal of Applied Toxicology : JAT·Na Liu, Meng Tang
Oct 10, 2020·Journal of Applied Toxicology : JAT·Xiaoquan Huang, Meng Tang
Jan 29, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ivana MirkovMilena Kataranovski
Jun 3, 2021·International Journal of Environmental Research and Public Health·Lishi ZhongTianshu Wu
Jun 11, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mengting ShangYuying Xue

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