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Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

bioRxiv

Mar 19, 2014

Ashley P NgWarren S. Alexander

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Abstract

Thrombopoietin (TPO) acting via its receptor Mpl is the major cytokine regulator of platelet number. To precisely define the role of specific hematopoietic cells in TPO dependent hematopoiesis, we generated mice that express the Mpl receptor normally on stem/progenitor cells but lack ex...read more

Mentioned in this Paper

Gene Expression
Hemostatic Function
Thrombopoietin Measurement
Megakaryocytes
Investigation of Megakaryocytes
MPL protein, human
Medial Pes Lemniscus
Myeloproliferation
Bone Marrow Cells
Hematopoietic Cell
1
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  • Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

    bioRxiv

    Mar 19, 2014

    Ashley P NgWarren S. Alexander

    PMID: 990003459

    DOI: 10.1101/003459

    Abstract

    Thrombopoietin (TPO) acting via its receptor Mpl is the major cytokine regulator of platelet number. To precisely define the role of specific hematopoietic cells in TPO dependent hematopoiesis, we generated mice that express the Mpl receptor normally on stem/progenitor cells but lack ex...read more

    Mentioned in this Paper

    Gene Expression
    Hemostatic Function
    Thrombopoietin Measurement
    Megakaryocytes
    Investigation of Megakaryocytes
    1

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