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Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

bioRxiv

Mar 19, 2014

Ashley P NgWarren S Alexander

Abstract

Thrombopoietin (TPO) acting via its receptor Mpl is the major cytokine regulator of platelet number. To precisely define the role of specific hematopoietic cells in TPO dependent hematopoiesis, we generated mice that express the Mpl receptor normally on stem/progenitor cells but lack ex...read more

Mentioned in this Paper

Myeloproliferation
TPO Signaling Pathway
MPL protein, human
Thrombopoiesis
Iodide Peroxidase
Megakaryocytes
Laboratory mice
Platelet Activation
Platelet Count Measurement
TPO Activity
1
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Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

bioRxiv

Mar 19, 2014

Ashley P NgWarren S Alexander

PMID: 990003459

DOI: 10.1101/003459

Abstract

Thrombopoietin (TPO) acting via its receptor Mpl is the major cytokine regulator of platelet number. To precisely define the role of specific hematopoietic cells in TPO dependent hematopoiesis, we generated mice that express the Mpl receptor normally on stem/progenitor cells but lack ex...read more

Mentioned in this Paper

Myeloproliferation
TPO Signaling Pathway
MPL protein, human
Thrombopoiesis
Iodide Peroxidase
Megakaryocytes
Laboratory mice
Platelet Activation
Platelet Count Measurement
TPO Activity
1

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