Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse

Human Molecular Genetics
Wendy M AartsenJan Wijnholds

Abstract

Membrane-associated guanylate kinase (MAGUK) proteins function as scaffold proteins contributing to cell polarity and organizing signal transducers at the neuronal synapse membrane. The MAGUK protein Mpp4 is located in the retinal outer plexiform layer (OPL) at the presynaptic plasma membrane and presynaptic vesicles of photoreceptors. Additionally, it is located at the outer limiting membrane (OLM) where it might be involved in OLM integrity. In Mpp4 knockout mice, loss of Mpp4 function only sporadically causes photoreceptor displacement, without changing the Crumbs (Crb) protein complex at the OLM, adherens junctions or synapse structure. Scanning laser ophthalmology revealed no retinal degeneration. The minor morphological effects suggest that Mpp4 is a candidate gene for mild retinopathies only. At the OPL, Mpp4 is essential for correct localization of Psd95 and Veli3 at the presynaptic photoreceptor membrane. Psd95 labeling is absent of presynaptic membranes in both rods and cones but still present in cone basal contacts and dendritic contacts. Total retinal Psd95 protein levels are significantly reduced which suggests Mpp4 to be involved in Psd95 turnover, whereas Veli3 proteins levels are not changed. These protein chang...Continue Reading

References

Apr 1, 1996·Current Biology : CB·J M Anderson
Oct 3, 1999·Nature Genetics·A I den HollanderA A Bergen
Oct 12, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S D DimitratosP J Bryant
Feb 7, 2001·The Journal of Biological Chemistry·E KamberovB Margolis
Apr 20, 2001·Biochimica Et Biophysica Acta·T C TsengA H Chishti
Aug 31, 2001·Nature Neuroscience·R H Masland
Dec 6, 2001·Human Molecular Genetics·A I den HollanderF P Cremers
May 15, 2002·The EMBO Journal·Carine BécamelPhilippe Marin
Sep 28, 2002·The Journal of Biological Chemistry·David KarnakBen Margolis
Oct 4, 2002·Current Biology : CB·Kevin JohnsonElisabeth Knust
Jan 3, 2003·Nature Cell Biology·David BilderNorbert Perrimon
Jul 16, 2003·Biochemical and Biophysical Research Communications·Man LiColin J Barnstable
Aug 2, 2003·American Journal of Physiology. Renal Physiology·Michael H Roh, Ben Margolis
Oct 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yang HongYuh-Nung Jan
Nov 26, 2003·Investigative Ophthalmology & Visual Science·Heidi StöhrBernhard H F Weber
Jul 22, 2004·Muscle & Nerve·Jamie L SanfordJill A Rafael-Fortney
Oct 2, 2004·Human Mutation·Anneke I den HollanderFrans P M Cremers
Oct 21, 2004·Biochemical Society Transactions·J MeulemanJ Wijnholds
Dec 30, 2004·Investigative Ophthalmology & Visual Science·Gareth J McKayGiuliana Silvestri
May 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Wei FengMingjie Zhang
May 26, 2005·Investigative Ophthalmology & Visual Science·Albena KantardzhievaJan Wijnholds
Sep 29, 2005·Vision Research·Mathias W SeeligerFelix Tonagel
Mar 8, 2006·The FEBS Journal·Albena KantardzhievaJan Wijnholds

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Citations

May 16, 2013·PloS One·Nawal Zabouri, Silke Haverkamp
Feb 26, 2014·Human Molecular Genetics·Lucie P PellissierJan Wijnholds
Feb 11, 2014·Progress in Retinal and Eye Research·Celso Henrique AlvesJan Wijnholds
Feb 5, 2014·Human Molecular Genetics·Celso Henrique AlvesJan Wijnholds
Feb 24, 2009·Molecular and Cellular Neurosciences·Wendy M AartsenJan Wijnholds
Oct 29, 2008·Experimental Eye Research·Johanna R FörsterHeidi Stöhr
Apr 15, 2008·Experimental Eye Research·Ilse GosensRonald Roepman
Aug 21, 2007·Glia·Serge A van de PavertJan Wijnholds
Apr 19, 2018·The Journal of Comparative Neurology·Ji-Jie PangSamuel M Wu
Dec 21, 2007·The Journal of Comparative Neurology·Silke HaverkampSusanne Tom Dieck
Aug 4, 2006·Human Molecular Genetics·Agnes G S H van RossumJan Wijnholds
Sep 22, 2006·Human Molecular Genetics·Mélisande RichardFrans P M Cremers
Aug 31, 2019·Scientific Reports·Jaimie Hoh KamGlen Jeffery
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka ChytłaAleksander Czogalla
Apr 14, 2021·Developmental Biology·Courtney A BurgerMelanie A Samuel
Jul 25, 2009·Journal of Cell Science·Natalia A Bulgakova, Elisabeth Knust

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