Mps one binder 2 gene upregulation in the stellation of astrocytes induced by cAMP-dependent pathway

Journal of Cellular Biochemistry
Kuan-Min FangShun-Fen Tzeng

Abstract

Astrocytes, the major glial population in the central nervous system (CNS), play an important role in neuronal homeostasis, neurogenesis, and synaptogenesis. The cells have a stellate shape with elaborated processes in the developing CNS. Cultured astrocytes become stellate when the cells undergo differentiation in response to stimuli. Nevertheless, the molecular mechanism for astrocytic stellation is poorly understood. Here, we showed that the addition of serum induced a flat polygonal shape in cultured astrocytes with a reduced level of Mps one binder 2 (Mob2) that is involved in neurite growth by forming stable complex with a nuclear Ser/Thr kinase Dbf2-related protein kinase 1 (NDR1). Furthermore, exposure to a membrane permeable cAMP analogue, dbcAMP, not only induced astrocytic stellation, but also caused an increase in Mob2 expression. Similarly, the upregulation of Mob2 mRNA expression was induced by exposure of astrocytes to pituitary adenylyl cyclase-activating polypeptide (PACAP). Pretreatment with a cAMP/protein kinase A (PKA) inhibitor, KT-5720, significantly blocked the effect of dbcAMP and PACAP on induced upregulation of Mob2 mRNA expression in astrocytes. In addition, the process withdrawal of dbcAMP-treated as...Continue Reading

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Citations

Jan 30, 2015·PloS One·Stefanie K SchweinhuberMartin Rothkegel
Jun 13, 2019·Cells·Ramazan Gundogdu, Alexander Hergovich
Aug 25, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Momotaj JahanYutaka Hata

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