MPTP-induced deficits in motor activity: neuroprotective effects of the spintrapping agent, alpha-phenyl-tert-butyl-nitrone (PBN)

Journal of Neural Transmission
A FredrikssonT Archer

Abstract

In Experiment 1, groups of mice were administered either saline or MPTP (2 x 30 mg/kg, s.c., separated by a 24-hr interval) 30 min after being injected either PBN (15, 50 or 150 mg/kg, s.c., low, medium and high doses, respectively) or L-Deprenyl (0.25 or 10.0 mg/kg, s.c., low and high doses, respectively), the reference compound used, or saline. Tests of spontaneous motor activity 14 days later indicated that the MPTP-induced hypokinesia for locomotion and rearing was alleviated by prior administration with PBN (50 or 150 mg/kg) or L-Deprenyl (10.0 mg/kg); lower doses of PBN (15 mg/kg) and L-Deprenyl (0.25 mg/kg) did not affect the MPTP-induced deficits. Dopamine (DA) concentrations in the striatum confirmed a more severe loss of DA in the MPTP, PBN (15) + MPTP and Deprenyl(0.25) + MPTP groups than in the control group. Significant protection of DA was observed in the PBN(50) + MPTP, PBN(150) + MPTP and Deprenyl(10) + MPTP groups that did not exhibit an hypokinetic behaviour. In Experiment 2, the effects of repeated treatment with PBN (50 mg/kg, s.c. over 12 days), post-MPTP, were studied in aged (15-month-old) and young (3-month-old) mice. Subchronic administration of PBN increased substantially the motor activity of old and ...Continue Reading

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Citations

Jun 22, 2006·Neurotoxicity Research·T Archer, A Fredriksson
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·B FergerW H Oertel
Jan 5, 2002·Journal of Neuroscience Methods·Pierre O FernagutFrançois Tison
Feb 28, 2003·Journal of Neuroscience Methods·Jennifer L Tillerson, Gary W Miller
Oct 30, 2001·Behavioural Brain Research·M SedelisJ P Huston
Jul 2, 2008·Parkinsonism & Related Disorders·P FoleyP Riederer
Mar 10, 2001·Antioxidants & Redox Signaling·Y Kotake
Aug 3, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Fang-Jung WanHui-Ching Lin
Jun 24, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Sara A WahdanAmani E Khalifa

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