MR-CBCT image-guided system for radiotherapy of orthotopic rat prostate tumors

PloS One
Tsuicheng D ChiuStrahinja Stojadinovic

Abstract

Multi-modality image-guided radiotherapy is the standard of care in contemporary cancer management; however, it is not common in preclinical settings due to both hardware and software limitations. Soft tissue lesions, such as orthotopic prostate tumors, are difficult to identify using cone beam computed tomography (CBCT) imaging alone. In this study, we characterized a research magnetic resonance (MR) scanner for preclinical studies and created a protocol for combined MR-CBCT image-guided small animal radiotherapy. Two in-house dual-modality, MR and CBCT compatible, phantoms were designed and manufactured using 3D printing technology. The phantoms were used for quality assurance tests and to facilitate end-to-end testing for combined preclinical MR and CBCT based treatment planning. MR and CBCT images of the phantoms were acquired utilizing a Varian 4.7 T scanner and XRad-225Cx irradiator, respectively. The geometry distortion was assessed by comparing MR images to phantom blueprints and CBCT. The corrected MR scans were co-registered with CBCT and subsequently used for treatment planning. The fidelity of 3D printed phantoms compared to the blueprint design yielded favorable agreement as verified with the CBCT measurements. The...Continue Reading

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Citations

Aug 29, 2019·Medical Physics·Nolan EsplenMagdalena Bazalova-Carter
May 28, 2020·Journal of Applied Clinical Medical Physics·Michael K RooneyDaniel W Golden
Dec 3, 2020·Cancer Research·Natalie J SerkovaRalph P Mason
Mar 30, 2021·International Journal of Radiation Oncology, Biology, Physics·Tatsuya J AraiRalph P Mason

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Methods Mentioned

BETA
X-Ray

Software Mentioned

XRad
SmART
Muriplan
Plan
MATLAB

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