PMID: 8448402Mar 1, 1993Paper

MR detection of quantitative and structural changes in human aortic aneurysms

Journal of Magnetic Resonance Imaging : JMRI
P VinéeB Eisenmann

Abstract

Collagen is a major component of the extracellular matrix and a determinant of the elastic behavior of the human aorta. To investigate the changes found in aneurysmal degeneration, the authors studied the solid-state hydrogen-1 nuclear magnetic resonance line shape of collagen in aneurysms and normal human aortas. A three-component decomposition of the free induction decay was performed, with collagen characterized by a T2 of about 18 microseconds. The second moment of the collagen line shape was found to be increased in aneurysms (5.3 vs 4.8 G2), while, correspondingly, the T2 of collagen was lower in aneurysms (16.3 vs 17.7 microseconds). This corresponds to a modification of collagen structure and molecular motion. Collagen concentration was lower in nondiseased aortic walls (9.4% vs 7.3%). These results are discussed in reference to the contradictory conclusions in the current literature. The increase in collagen and the modification of its structure and molecular motion are explained by the need to resist an increasing tangential tension due to increased aortic diameter and diminished wall thickness in aneurysms and by intercalation or site binding in the helices or electric dipolar interactions in the less mobile side gro...Continue Reading

References

Sep 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·P VinéeJ Hennig
Feb 1, 1989·Journal of Vascular Surgery·J Powell, R M Greenhalgh
Oct 1, 1989·Journal of Vascular Surgery·R J RizzoJ S Yao
Sep 1, 1973·Progress in Cardiovascular Diseases·I Gore, A E Hirst
Jan 1, 1982·Magnetic Resonance Imaging·P T Beall
Mar 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P VinéeJ Laubenberger

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