MR diffusion kurtosis imaging for neural tissue characterization

NMR in Biomedicine
Ed X Wu, Matthew M Cheung

Abstract

In conventional diffusion tensor imaging (DTI), water diffusion distribution is described as a 2nd-order three-dimensional (3D) diffusivity tensor. It assumes that diffusion occurs in a free and unrestricted environment with a Gaussian distribution of diffusion displacement, and consequently that diffusion weighted (DW) signal decays with diffusion factor (b-value) monoexponentially. In biological tissue, complex cellular microstructures make water diffusion a highly hindered or restricted process. Non-monoexponential decays are experimentally observed in both white matter and gray matter. As a result, DTI quantitation is b-value dependent and DTI fails to fully utilize the diffusion measurements that are inherent to tissue microstructure. Diffusion kurtosis imaging (DKI) characterizes restricted diffusion and can be readily implemented on most clinical scanners. It provides a higher-order description of water diffusion process by a 2nd-order 3D diffusivity tensor as in conventional DTI together with a 4th-order 3D kurtosis tensor. Because kurtosis is a measure of the deviation of the diffusion displacement profile from a Gaussian distribution, DKI analyses quantify the degree of diffusion restriction or tissue complexity witho...Continue Reading

References

Nov 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Beaulieu, P S Allen
Dec 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M D KingD G Gadian
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Jun 1, 1996·Journal of Magnetic Resonance. Series B·P J Basser, C Pierpaoli
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T NiendorfK Nicolay
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Pierpaoli, P J Basser
Jan 1, 1997·Advances and Technical Standards in Neurosurgery·K G Go
Apr 9, 1999·NMR in Biomedicine·R V MulkernS E Maier
Nov 26, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R XueS Mori
Feb 19, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y Assaf, Y Cohen
Oct 24, 2000·Journal of Magnetic Resonance Imaging : JMRI·B QuessonC T Moonen
Dec 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C A Clark, D Le Bihan
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S MoriP Yarowsky
Jan 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y AssafY Cohen
Apr 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chris A ClarkMichael E Moseley
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lawrence R Frank
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D C AlexanderS R Arridge
Sep 28, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David S TuchVan J Wedeen
Nov 6, 2002·Journal of the Neurological Sciences·Y AssafA D Korczyn
Nov 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Masaya TakahashiMichael E Selzer
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark D DoesJohn C Gore
Oct 3, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin M BennettJames S Hyde
Oct 3, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shu-Wei SunSheng-Kwei Song
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Evren Ozarslan, Thomas H Mareci
Dec 4, 2003·NMR in Biomedicine·Yuji SuzukiTsutomu Nakada
Feb 3, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Khader M HasanPonnada A Narayana
May 4, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chunlei LiuMichael E Moseley
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sang-Pil LeeJoseph A Helpern
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Derek K Jones, Peter J Basser
Apr 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ragini VermaChristos Davatzikos
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shu-Wei SunSheng-Kwei Song
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens H JensenKyle Kaczynski
Jun 18, 2005·NeuroImage·Lindsay SnookChristian Beaulieu
Jul 20, 2005·Journal of Magnetic Resonance Imaging : JMRI·Steren ChabertDenis Le Bihan
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Charlotte J Yong-HingGordon E Sarty
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chunlei LiuMichael E Moseley
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Itamar RonenDae-Shik Kim
Jan 7, 2006·Journal of Neuroscience Research·Laura A HarsanM Said Ghandour

❮ Previous
Next ❯

Citations

May 30, 2013·Clinical Neuroradiology·Yuzhen ZhangYuhua Li
Oct 26, 2012·Neuroradiology·Kei YamadaToshiki Mizuno
Mar 14, 2012·European Radiology·Masaaki HoriShigeki Aoki
Jun 6, 2013·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Xu YanDongrong Xu
Dec 29, 2013·AJR. American Journal of Roentgenology·Andrew J StevenElias R Melhem
Oct 25, 2012·Radiology·Marco GiannelliCarlo Tessa
Jul 21, 2011·Radiology·Jiun-Jie WangYau-Yau Wai
Jun 6, 2013·Neural Plasticity·Lin JiangChunshui Yu
Mar 10, 2012·Radiology·Sofie Van CauterStefan Sunaert
Mar 13, 2012·Translational Stroke Research·Rick M DijkhuizenMaurits P A van Meer
May 2, 2014·Journal of Neurotrauma·Andrew B DoddAndrew R Mayer
May 24, 2012·Brain Structure & Function·Bjørnar T AntonsenTrygve B Leergaard
Dec 3, 2014·Neuroimaging Clinics of North America·John L UlmerLeighton P Mark
Jul 8, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nils H UlrichSpyros S Kollias
Nov 28, 2012·AJNR. American Journal of Neuroradiology·E J GrossmanR I Grossman
Dec 27, 2015·Magnetic Resonance Imaging·Marco Giannelli, Nicola Toschi
Dec 3, 2014·NeuroImage·Marloes J A G HenckensMarian Joëls
Feb 5, 2016·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kouhei KamiyaKuni Ohtomo
Feb 3, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anna M WangEd X Wu
Jun 25, 2015·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Suguru YokosawaKohsuke Kudo
Jun 7, 2011·Neuroimaging Clinics of North America·Steve H FungPamela W Schaefer
May 24, 2011·Magnetic Resonance Imaging·Silvia De SantisSilvia Capuani
Mar 26, 2011·Neurosurgery Clinics of North America·Lauren J O'Donnell, Carl-Fredrik Westin
Dec 3, 2014·NeuroImage·Edward S HuiJens H Jensen
Sep 25, 2015·NeuroImage·Nathaniel D KelmMark D Does
Mar 10, 2016·Neurology India·Aditya Vedantam, Vedantam Rajshekhar
Jun 25, 2015·International Journal of Radiation Oncology, Biology, Physics·Priyanka P PramanikYue Cao
Sep 20, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Li Xiao, Ed X Wu
May 12, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S PortnoyG J Stanisz
Dec 14, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Els FieremansJens H Jensen
Oct 5, 2012·Journal of Magnetic Resonance Imaging : JMRI·Alicia W YangJoseph A Helpern
Apr 17, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Brian HansenSune Nørhøj Jespersen
Nov 22, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Iris Y ZhouEd X Wu
Nov 20, 2013·Journal of Magnetic Resonance Imaging : JMRI·Masaki KatsuraKuni Ohtomo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.