MR diffusion-weighted imaging and outcome prediction after ischemic stroke

Neurology
P J HandM S Dennis

Abstract

MR diffusion-weighted imaging (DWI) shows acute ischemic lesions early after stroke so it might improve outcome prediction and reduce sample sizes in stroke treatment trials. Previous studies of DWI and outcome produced conflicting results. To determine whether DWI lesion characteristics independently predict outcome in a broad range of patients with acute stroke. The authors recruited hospital-admitted patients with all severities of suspected stroke, assessed stroke severity on the NIH Stroke Scale (NIHSS), performed early brain DWI, and assessed outcome at 3 months (modified Rankin Scale). Clinical data and DWI lesion parameters were evaluated in a logistic regression model to identify independent predictors of outcome at 3 months and a previously described "Three-Item Scale" (including DWI) was tested for outcome prediction. Among 82 patients (mean NIHSS 7.1 [+/-6.3 SD]), the only independent outcome predictors were age and stroke severity. Neither DWI lesion volume nor apparent diffusion coefficient nor the previously described Three-Item Scale predicted outcome independently. Comparison with previous studies suggested that DWI may predict outcome only in patients with more severe cortical ischemic strokes. Across a broad ...Continue Reading

Citations

Jul 26, 2008·Der Nervenarzt·P RinglebUNKNOWN Europäischen Schlaganfallorganisation
Nov 9, 2007·Journal of Neurology·I Korn-LubetzkiB Steiner-Birmanns
Oct 20, 2010·Journal of Neurology·Hideaki TeiKuniko Ohara
Jan 16, 2010·Medical & Biological Engineering & Computing·David N KennedyVerne S Caviness
Mar 20, 2010·Brain : a Journal of Neurology·Dorothee SaurStefan Klöppel
Oct 7, 2009·Cerebral Cortex·Vincenzo Di LazzaroM Dileone
May 11, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S T EngelterP A Lyrer
Jan 1, 2011·ISRN Neurology·Denis SablotElisabeth Medeiros de Bustos
Aug 22, 2007·American Journal of Physical Medicine & Rehabilitation·M Maria GlymourKaren L Furie
Feb 22, 2012·Insights Into Imaging·Erick AmarteifioMarc-André Weber
Feb 22, 2012·Journal of Neuroradiology. Journal De Neuroradiologie·A AttyéJ-F Le Bas
Mar 1, 2011·Trends in Neurosciences·Berislav V Zlokovic, John H Griffin
Aug 30, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nirmalya GhoshStephen Ashwal
Jan 21, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tracy D Farr, Susanne Wegener
Aug 28, 2007·Methods : a Companion to Methods in Enzymology·Feng ChenYicheng Ni
Aug 11, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Carly S RiversMartin S Dennis
Jan 3, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Cathy M Stinear, Nick S Ward
Nov 3, 2015·Physical Medicine and Rehabilitation Clinics of North America·Richard L Harvey
Jan 19, 2011·Acta Neurologica Scandinavica·A MuscariM Zoli
May 22, 2016·Journal of the Neurological Sciences·Lumeng YangQiang Dong
Feb 14, 2012·Journal of the Neurological Sciences·Kyung-Hee ChoDong-Wha Kang
Oct 12, 2014·Journal of the Neurological Sciences·Seung Min KimDong-Wha Kang
Sep 21, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L HanneM Ebinger
May 15, 2008·Cerebrovascular Diseases·UNKNOWN European Stroke Organisation (ESO) Executive Committee, UNKNOWN ESO Writing Committee
Dec 1, 2010·The Neuroradiology Journal·F TortoraS Cirillo
Aug 10, 2016·Neurorehabilitation and Neural Repair·Bokkyu Kim, Carolee Winstein
Dec 2, 2017·Journal of Clinical Pharmacology·Hyeong-Seok LimDong-Wha Kang
May 23, 2012·Nature Reviews. Neurology·Christian Weimar
Mar 1, 2018·Annual Review of Neuroscience·Cassandra Sampaio-BaptistaHeidi Johansen-Berg
Feb 14, 2014·Stroke; a Journal of Cerebral Circulation·Amy KuceyeskiCostantino Iadecola
Mar 7, 2014·Stroke; a Journal of Cerebral Circulation·Wolf-Dieter Heiss, Chelsea S Kidwell
Apr 21, 2007·Stroke; a Journal of Cerebral Circulation·Karen C JohnstonUNKNOWN GAIN, Citicoline, and ASAP Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.