MR findings in leukodystrophy

Neuroradiology
P DemaerelA L Baert

Abstract

Up to 5 years ago, the radiological diagnosis of leukodystrophy was based on computed tomography (CT). More recently, magnetic resonance imaging (MRI) has been used to study pathology of the white matter with great success. The abnormalities in eight patients with different types of leukodystrophy are described, using high-field MRI. CT and MRI show comparable sensitivity in detecting the pathological changes of leukodystrophy. MRI seems to be superior in visualizing the extent of the lesions, their precise anatomical location and any involvement of the brain stem and cerebellum. Differential diagnosis among the three types of leukodystrophy by MRI is difficult but may be attempted by some features. Specific diagnosis can be achieved only by laboratory examination or histology. The role of MRI should be to suggest the proper biochemical test at an earlier stage.

References

Jan 1, 1990·Neuroradiology·P DemaerelA L Baert
Jan 1, 1990·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M E JensenW B Rizzo
Aug 1, 1988·AJR. American Journal of Roentgenology·M A NowellL T Bilaniuk
Jul 1, 1988·Radiology·M J KuhnK R Davis
Sep 1, 1988·Archives of Neurology·J D SchwankhausH McFarland
Nov 1, 1987·Radiology·A J KumarH S Mayberg
Jan 1, 1986·Neurology·T Z BaramA K Percy

Citations

Jun 24, 2011·Journal of Inherited Metabolic Disease·Samuel GroeschelIngeborg Krägeloh-Mann
Sep 15, 1996·Journal of the Neurological Sciences·A NezuN Ohtsuki
May 1, 1995·Brain & Development·A Nezu
Mar 1, 1996·Brain & Development·A NezuC Kawanishi
Dec 11, 1999·Pediatric Neurology·D I ZafeiriouN P Gombakis
Nov 3, 2010·Bone Marrow Transplantation·L D de HossonA V M B Schattenberg
May 15, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jung-Eun CheonKyung Mo Yeon
Apr 28, 2012·AJNR. American Journal of Neuroradiology·A MartinC Adamsbaum
Jun 24, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·E HaberlandtR Korinthenberg
Dec 23, 2006·Paediatric Anaesthesia·Cristina MattioliLuigi Beretta
Dec 21, 2004·Journal of Child Neurology·Peter B Barker, Alena Horská
Aug 8, 2018·Topics in Magnetic Resonance Imaging : TMRI·Felice D'ArcoAjay Taranath
Jan 1, 1993·Pediatric Radiology·P J CloseK T Nolan
Mar 7, 2019·Journal of Healthcare Engineering·Zhenglun KongShengpu Xu

Related Concepts

Teens
Adrenomyeloneuropathy
Brain
Alpers Syndrome (Disorder)
Late-Onset Globoid Cell Leukodystrophy
Arylsulfatase A Deficiency

Related Feeds

Adrenoleukodystrophy

Adrenoleukodystrophy (ALD), the most frequent peroxisomal disorder, is an X-linked disorder caused by a defect in the metabolism of long chain fatty acids leading to demyelination, neurodegeneration, and death. Here is the latest research.