MR imaging based fractal analysis for differentiating primary CNS lymphoma and glioblastoma

European Radiology
Shuai LiuTao Jiang

Abstract

The aim of this study was to differentiate primary central nervous system lymphoma (PCNSL) from glioblastomas (GBM) using the fractal analysis of conventional MRI data. Sixty patients with PCNSL and 107 patients with GBM with MRI data available were enrolled. Fractal dimension (FD) and lacunarity values of the tumour region were calculated using fractal analysis. A predictive model combining fractal parameters and anatomical characteristics was built using logistic regression. The role of FD, lacunarity and the predictive model in differential diagnosis was evaluated using receiver-operating characteristic (ROC) curve analysis. The association between fractal parameters and anatomical characteristics of tumours was also investigated. PCNSL had lower FD values (p < 0.001) and higher lacunarity values (p < 0.001) than GBM. ROC curve analysis revealed that FD, lacunarity, and the predictive model could distinguish PCNSL from GBM (area under the curve: 0.895, 0.776, and 0.969, respectively). The following associations were observed between fractal parameters and anatomical characteristics: multiple lesions were significantly associated with higher lacunarity (p = 0.024), necrosis with higher FD (p = 0.027), corpus callosum involvem...Continue Reading

References

May 1, 1997·The Journal of Pathology·S S Cross
Nov 26, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L G Nyúl, J K Udupa
Jul 24, 2001·Methods : a Companion to Methods in Enzymology·E Fernández, H F Jelinek
Jun 1, 2005·Journal of Neuro-oncology·Wilhelm KükerUlrich Herrlinger
Aug 27, 2005·Dento Maxillo Facial Radiology·F Yasar, F Akgünlü
May 25, 2007·Neuro-oncology·Suvi LarjavaaraAnssi Auvinen
Jan 24, 2009·AJNR. American Journal of Neuroradiology·I S HaldorsenA Espeland
Jan 30, 2014·Cancers·Maria-Del-Mar IndaJoan Seoane
Jul 8, 2015·The Lancet Oncology·Khê Hoang-XuanUNKNOWN European Association for Neuro-Oncology Task Force on Primary CNS Lymphoma
Jul 15, 2015·Nature Reviews. Clinical Oncology·Frances E LennonRavi Salgia
Nov 30, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·H MalikovaZ Vojtech
May 10, 2017·The Lancet Oncology·Michael WellerUNKNOWN European Association for Neuro-Oncology (EANO) Task Force on Gliomas

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Related Papers

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
Shixing BaoNoriyuki Tomiyama
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Hong-yan LiuShi-jun Qiu
Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Dong ZhangLi Wen
Arquivos de neuro-psiquiatria
Elizabete Maria Pereira de Andrade CairesAntônio Alberto Zambon
© 2022 Meta ULC. All rights reserved