MR Imaging Characteristics of Wingless-Type-Subgroup Pediatric Medulloblastoma

AJNR. American Journal of Neuroradiology
Z PatayD W Ellison

Abstract

"Transcriptionally different" medulloblastoma groups are associated with specific signaling pathway abnormalities; hence, they may present with distinct imaging manifestations. In this study, we sought to describe the MR imaging features of wingless-type-subgroup medulloblastomas with embryologic correlations. Pre- and postoperative imaging studies of 16 patients with wingless-type-subgroup medulloblastoma were evaluated for tumor location, involvement of surrounding CSF spaces or parenchymal structures, conventional and DWI signal properties, and postsurgical damage patterns. Laterality scores were assigned to tumors at each step in the evaluation process. Continuous variables were summarized by using descriptive statistics. The Wilcoxon signed rank test was performed to compare laterality scores. To determine the interobserver variability, we computed the intraclass correlation and Cohen κ coefficients. Wingless-type-subgroup medulloblastomas in our series were histopathologically "classic." Wingless-type-subgroup medulloblastomas occur in specific sites, with involvement of the foramen of Luschka (75%), the fourth ventricle (68.75%), the cisterna magna (31.25%), and the cerebellopontine angle cistern (18.75%). Laterality sco...Continue Reading

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Citations

Jul 18, 2016·Neuroimaging Clinics of North America·Asim F ChoudhriPaul Klimo
Oct 16, 2016·Magnetic Resonance Imaging Clinics of North America·Asim F ChoudhriPaul Klimo
May 31, 2016·Neurologia Medico-chirurgica·Noriyuki Kijima, Yonehiro Kanemura
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Dec 6, 2018·Topics in Magnetic Resonance Imaging : TMRI·Guilherme de Souza E CassiaZoltan Patay
Jun 13, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Nihaal ReddyZoltan Patay
Jul 7, 2018·Therapeutic Advances in Neurological Disorders·Giovanna Stefania ColafatiAngela Mastronuzzi
Aug 19, 2018·Pediatric Radiology·Felice D'ArcoSotirios Bisdas
Dec 14, 2018·AJNR. American Journal of Neuroradiology·M IvK W Yeom
Jun 2, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Stefan SchobAlexey Surov
May 9, 2019·Neurosurgery·Dominik ReisingerIrene Slavc
Sep 11, 2019·Neuro-oncology·Rashad JabarkheelVijay Ramaswamy
Jan 20, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jonas ReisRobert Forbrig
Mar 6, 2021·AJNR. American Journal of Neuroradiology·C A P F AlvesF D'Arco
Jun 20, 2020·Developmental Cell·Deanna M PatmoreRichard J Gilbertson
Sep 23, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yavuz ArasAli Nail İzgi

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