MR imaging-detected carotid plaque hemorrhage is stable for 2 years and a marker for stenosis progression.

AJNR. American Journal of Neuroradiology
R J SimpsonN Altaf

Abstract

MR imaging-detected carotid plaque hemorrhage is associated with an increased risk of recurrent ischemic cerebrovascular events and could be an indicator of disease progression; however, there are limited data regarding the dynamics of the MR imaging-detected carotid plaque hemorrhage signal. We assessed the temporal change of this signal and its impact on carotid disease progression. Thirty-seven symptomatic patients with 54 carotid stenoses of >30% on sonography underwent serial MR imaging during 24 months. A signal-intensity ratio of >1.5 between the carotid plaque and adjacent muscle was defined as plaque hemorrhage, and a change in signal-intensity ratio of >0.31 between time points was considered significant. Sixteen patients underwent ≥2 carotid sonography scans to determine the peak systolic velocities and degree of stenosis with time. Of the 54 carotids, 28 had the presence of hyperintense signal on an MR imaging sequence (PH+) and 26 had the absence of hyperintense signal on an MR imaging sequence (PH-) at baseline. The signal-intensity ratio was stable in 33/54 carotid plaques, but 39% showed a change. Plaque hemorrhage classification did not change in 87% of carotid plaques, but 4 became PH+, and 3, PH-. As a group,...Continue Reading

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Citations

Jan 23, 2016·Thrombosis and Haemostasis·Lambert SpeelmanJonathan H Gillard
Nov 28, 2015·Neuroimaging Clinics of North America·Alan R Moody, Navneet Singh
Jul 20, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Jin LiuChun Yuan
Nov 5, 2016·Nature Reviews. Cardiology·Gerard PasterkampPeter Libby
Mar 13, 2019·Journal of Magnetic Resonance Imaging : JMRI·Jin LiuChun Yuan
Nov 19, 2019·Journal of Neurosurgical Sciences·Seyed M SeyedsaadatWaleed Brinjikji
Feb 6, 2020·The International Journal of Cardiovascular Imaging·Tianwen HanXue-Qiao Zhao

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