MR imaging of hydrogel filament embolic devices loaded with superparamagnetic iron oxide or gadolinium.

Neuroradiology
M KillerM R McCoy

Abstract

We evaluated hydrogel filaments loaded with barium sulphate and either gadolinium or superparamagnetic iron oxide (SPIO) in an effort to develop an embolic material that is visible with fluoroscopic and magnetic resonance imaging. Hydrogel filaments were prepared with gadolinium and iron concentrations ranging from 1,500 to 7,500 and 500 to 2,500 ppm, respectively. The filaments were encased in agar and imaged using an MR scanner. Embolisation of eight aneurysms (seven bifurcation, one sidewall) in seven rabbits was performed using hydrogel filaments loaded with gadolinium (n = 4) or SPIO (n = 4). Angiographic evaluations occurred immediately post-treatment and at 13 weeks. Magnetic resonance angiography (MRA) evaluations occurred immediately post-treatment or 13 weeks post-treatment. Based on the in vitro results, we selected 4,500 and 2,000 ppm for gadolinium and iron loadings, respectively, for the in vivo experiments. Loading the filaments with gadolinium or SPIO did not affect the angiographic results, as embolic masses were readily evident with some distinguishing of individual filaments. In MRA, the hydrogel filaments loaded with SPIO were hypointense, and the hydrogel filaments loaded with Gd were hyperintense. The hype...Continue Reading

References

Dec 5, 1998·Journal of Vascular and Interventional Radiology : JVIR·X YangE Atalar
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·D RoyJ Raymond
Jun 2, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anthony Z FaraneshElliot R McVeigh
Mar 24, 2006·Journal of Magnetic Resonance Imaging : JMRI·Daniel R ElgortJeffrey L Duerk
Mar 24, 2006·Journal of Magnetic Resonance Imaging : JMRI·Orhan UnalCharles M Strother
May 10, 2007·Magma·Olaf Saborowski, Maythem Saeed
Oct 4, 2007·Journal of Vascular and Interventional Radiology : JVIR·Julien NamurAlex Laurent
Oct 1, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michael J ConstantGregory M Cruise
Oct 31, 2008·AJNR. American Journal of Neuroradiology·M E SprengersC B L M Majoie
Dec 31, 2008·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Kanishka RatnayakaRobert J Lederman
May 29, 2009·AJNR. American Journal of Neuroradiology·M KillerG M Cruise

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Citations

Apr 13, 2013·Cardiovascular and Interventional Radiology·Ruben Lopez-BenitezJoachim Kettenbach
Mar 10, 2015·IEEE Transactions on Nanobioscience·Kyoung Duck SeoDong Sung Kim
Jul 12, 2014·Tissue Engineering. Part B, Reviews·Seung Yun NamStanislav Y Emelianov
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Yang HeJun Cao

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