MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders

Radiology
D Le BihanM Laval-Jeantet

Abstract

Molecular diffusion and microcirculation in the capillary network result in a distribution of phases in a single voxel in the presence of magnetic field gradients. This distribution produces a spin-echo attenuation. The authors have developed a magnetic resonance (MR) method to image such intravoxel incoherent motions (IVIMs) by using appropriate gradient pulses. Images were generated at 0.5 T in a high-resolution, multisection mode. Diffusion coefficients measured on images of water and acetone phantoms were consistent with published values. Images obtained in the neurologic area from healthy subjects and patients were analyzed in terms of an apparent diffusion coefficient (ADC) incorporating the effect of all IVIMs. Differences were found between various normal and pathologic tissues. The ADC of in vivo water differed from the diffusion coefficient of pure water. Results were assessed in relation to water compartmentation in biologic tissues (restricted diffusion) and tissue perfusion. Nonuniform slow flow of cerebrospinal fluid appeared as a useful feature on IVIM images. Observation of these motions may significantly extend the diagnostic capabilities of MR imaging.

Associated Clinical Trials

Oct 20, 2015·Lawrence Schwartz

Citations

Sep 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A MancusoP R Weinstein
Nov 15, 2011·European Radiology·Hildebrand DijkstraPaul E Sijens
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Feb 21, 2004·Academic Radiology·Marek KubickiMartha E Shenton
Mar 18, 2010·Nature Methods·Thomas WalterJean-Karim Hériché
Jun 11, 2009·Topics in Magnetic Resonance Imaging : TMRI·Michael A JacobsKatarzyna J Macura
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Muriel PerrinDenis Lebihan
Oct 4, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Elizabeth M Charles-Edwards, Nandita M deSouza
Sep 4, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Robert Hermans, Vincent Vandecaveye
Jan 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·I Moseley
Oct 17, 2008·Physiological Reviews·Eva Syková, Charles Nicholson
Mar 24, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Ye QiaoJames A Hamilton
Oct 6, 2000·The Journal of Clinical Investigation·Z G ZhangM Chopp
Mar 30, 2013·BMC Cardiovascular Disorders·Delphine PériéDaniel Curnier
Dec 29, 2012·PloS One·Alessandro DaducciJean-Philippe Thiran
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hao HuangSusumu Mori
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura-Adela HarsanM Said Ghandour
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffry R Alger
Jan 28, 2010·Journal of Rehabilitation Research and Development·Robert W Van BovenMichael W Weiner
Jan 1, 2014·World Journal of Gastroenterology : WJG·Feng ChenYi-Cheng Ni
Jan 1, 2011·Journal of Radiology Case Reports·Hima Shriniwas PendharkarMuraleedharan Nair
Mar 25, 2011·The Indian Journal of Radiology & Imaging·Paramjeet SinghNiranjan Khandelwal
Apr 8, 2014·EMBO Molecular Medicine·Denis Le Bihan
Jul 20, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Reiko WoodhamsYusuke Inoue

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.