MR imaging of the liver with Resovist: safety, efficacy, and pharmacodynamic properties

Radiology
A F KoppC D Claussen

Abstract

To evaluate the safety, efficacy, and pharmacodynamic properties of a new superparamagnetic parenteral iron oxide contrast agent for magnetic resonance (MR) imaging. Thirty-six patients with liver lesions received a bolus injection of Resovist (SH U 555 A; Schering, Berlin, Germany) at a dose of 4, 8, or 16 micromol iron per kilogram body weight (micromol Fe/kg). Fast low-angle shot, spin-echo, and turbo gradient spin-echo MR images were obtained before and 10, 40, and 70 minutes after injection. Blood samples were obtained, vital signs were monitored, and adverse events were recorded. Lesion detection was assessed by two independent, blinded readers. No drug-related adverse events occurred. Serum iron and ferritin levels were increased at all dose levels. Partial thromboplastin time increased and factor XI level decreased 4 hours after injection of 16 micromol Fe/kg. Lesion detection and diagnostic confidence were increased in patients who received 4 or 8 micromol Fe/kg, with no further increase with a 16-micromol dose. Resovist is safe and effective. The best MR imaging results were obtained 40 minutes after injection of 8 micromol Fe/kg.

Citations

Dec 20, 2011·World Journal of Gastroenterology : WJG·Ling-Hui XuWei-Jun Peng
Jan 1, 2005·European Radiology·Marie-France BellinUNKNOWN Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)
Aug 25, 2006·AJR. American Journal of Roentgenology·Myeong-Jin KimDonald G Mitchell
Apr 30, 2002·Investigative Radiology·Naoki KatoTomoaki Miyazawa
Dec 18, 2001·Journal of Magnetic Resonance Imaging : JMRI·D T KehagiasL J Vlahos
Oct 3, 2002·Topics in Magnetic Resonance Imaging : TMRI·Giovanni MoranaCarlo Procacci
Feb 1, 2006·Abdominal Imaging·H S ThomsenUNKNOWN ESUR
Apr 7, 2012·Chemical Society Reviews·Miriam ColomboWolfgang J Parak
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R Ros, G L Davis
Nov 26, 2008·Journal of Magnetic Resonance Imaging : JMRI·Kengo TomitaToshifumi Hibi
Dec 20, 2008·Journal of Magnetic Resonance Imaging : JMRI·Hiromitsu OnishiHironobu Nakamura
Nov 27, 2007·Journal of Tissue Engineering and Regenerative Medicine·H PereaE Wintermantel
Mar 6, 2007·Journal of Magnetic Resonance Imaging : JMRI·Sook NamkungStefan O Schoenberg
Jan 21, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·B DeloisonL J Salomon
Apr 26, 2012·Journal of Magnetic Resonance Imaging : JMRI·Akihiro NishieHiroshi Honda
Sep 29, 2006·European Journal of Radiology·Marie-France Bellin
Apr 1, 1998·Radiologic Clinics of North America·P F Hahn, S Saini
Oct 2, 2008·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kazuhiro SaitoKimihiko Abe
Aug 6, 2005·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kazuhiro SaitoKimihiko Abe
Mar 18, 2006·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kazuhiro SaitoKimihiko Abe
Aug 22, 2017·Radiology·Heike E Daldrup-Link

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Dimosthenis StamopoulosKostantinos Papadopoulos
© 2022 Meta ULC. All rights reserved