MR mammography using diffusion-weighted imaging in evaluating breast cancer: a correlation with proliferation index

La Radiologia medica
Cristina MolinariMassimo Bazzocchi

Abstract

To evaluate whether the variation of the apparent diffusion coefficient (ADC) values obtained with DWI can predict elevated levels of Ki67 proliferation index and aggressive subtypes in patients with breast cancer. Breast MRI studies of 115 patients (mean age 57.3 years, range 36-81 years) with a biopsy-proven breast cancers were evaluated in this retrospective IRB-approved study. Examinations were performed on a 1.5 T magnet and included a Single-Shot Echoplanar DWI sequence with b values of 0 and 1000 s/mm(2). For each target lesion, ADC was measured. ADC values were compared considering Ki67 status (≥20 % or <20 %), histology, grade (G1, G2 or G3) and clinical-pathological classification (Luminal A, Luminal B HER2-positive, Luminal B HER-2 negative, HER-2 enriched and Triple Negative). Mann-Whitney U test and Kruskal-Wallis test were used for comparisons and receiver operating characteristic (ROC) curves were obtained. Inter- and intra-reader variability was evaluated in a subset of 40 patients, using interclass correlation coefficient (ICC) and Bland-Altman plots. Of 115 lesions, 53 (46.1 %) were assessed as Ki67 positive and 62 (53.9 %) as Ki67 negative. ADC values were significantly (p < 0.0001) lower in Ki67-positive pat...Continue Reading

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Citations

Sep 24, 2016·Journal of Magnetic Resonance Imaging : JMRI·Can OnaygilErkin Aribal
Apr 19, 2017·International Journal of Molecular Sciences·Mariarosaria IncoronatoMarco Salvatore
Sep 30, 2017·Topics in Magnetic Resonance Imaging : TMRI·Savannah C Partridge, Nita Amornsiripanitch
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Feb 17, 2017·British Journal of Cancer·Onofrio Antonio CatalanoBruce Robert Rosen
Apr 27, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Mariarosaria IncoronatoMarco Salvatore

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