PMID: 9438440Jan 23, 1998Paper

MR microscopy of lung airways with hyperpolarized 3He

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
X J ChenG A Johnson

Abstract

A technique using hyperpolarized (HP) 3He to image the small airways of the lung by using moderate flip angles and a short scanning period during early inspiration is demonstrated. Flip angles (alpha) ranging from 10-90 degrees were used in guinea pig experiments with scanning during the entire inspiration period. A second series acquired data throughout a short window of the ventilatory cycle with alpha = 45 degrees. The success of the animal studies has motivated implementation of similar imaging techniques in the clinical arena. Human studies involved imaging over the total inspiration period with alpha approximately 10 degrees. The first series of guinea pig experiments demonstrated that larger flip angles (50-90 degrees) destroy the magnetization before it reaches the smaller airways. At moderate flip angles (20-40 degrees), airway branching down to the fourth generation was apparent. Fifth-order branchings were seen in the images of the second series. The trachea down to fourth generation pulmonary airway branching, along with some distal air spaces, was seen in the human lung images.

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Citations

Jun 18, 1999·Journal of Magnetic Resonance Imaging : JMRI·K W StockR R Edelman
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y CrémillieuxA Briguet
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H E MöllerG A Johnson
Jun 17, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F KoberA Ziegler
Sep 30, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X J ChenG A Johnson
Jun 27, 2000·NMR in Biomedicine·L W HedlundG A Johnson
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H E MöllerG A Johnson
Oct 13, 2001·Journal of Magnetic Resonance Imaging : JMRI·T NakagawaK Takeda
Mar 1, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jie ZhengMark S Conradi
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yoshiharu OhnoKazuro Sugimura
Jan 2, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ben T ChenG Allan Johnson
Oct 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M SalernoJ P Mugler
May 7, 2004·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Binquan WangRahim R Rizi
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Apr 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai RuppertJohn P Mugler
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Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Harald E MöllerHans-Ulrich Kauczor
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Oct 10, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Harry Karmouty QuintanaNicolau Beckmann
Jul 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X J ChenG A Johnson
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Oct 26, 2010·Contrast Media & Molecular Imaging·Katarzyna CieślarYannick Crémillieux

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