MR multispectral analysis of multiple sclerosis lesions

Journal of Magnetic Resonance Imaging : JMRI
J R MitchellA Fenster

Abstract

Although quantification of the lesion burden from serial MR examinations of patients with multiple sclerosis (MS) is a common technique to assess disease activity in clinical trials, pathologic change may occur within a lesion without a corresponding change in volume. Therefore, measures of lesion volume and composition may improve the sensitivity of detecting disease activity. A new technique has been developed that provides information about the intensity composition of MS lesions in standard spin-echo MR examinations. The new technique is based on the multispectral "feature space" intensity distributions of the lesions and normal tissues. Analysis of MR examinations of materials with known T1 and T2 times showed that feature space position from spin-echo examinations is largely determined from proton density (rho), T2, and the interecho delay. Information about intensity composition was obtained by reducing the multidimensional intensity distribution to one dimension while minimizing the loss of information. This technique was used to analyze eight lesions in standard spin-echo MR examinations of three patients with MS. Lesion distributions were compared between examinations by first calibrating the examinations based on the...Continue Reading

References

Mar 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F PannizzoP T Cahill
Apr 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S J KarlikJ H Noseworthy
Jul 1, 1991·Neurology·B G WeinshenkerG P Rice
Aug 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·D H MillerA J Thompson
Aug 1, 1991·Journal of the Neurological Sciences·L RumbachM Collard
Apr 1, 1991·Brain : a Journal of Neurology·W A StewartD W Paty
Mar 10, 1990·BMJ : British Medical Journal·A J ThompsonW I McDonald
Nov 1, 1990·Neurology·J S WolinskyM J Fenstermacher
Dec 1, 1989·NMR in Biomedicine·S S GillS R Williams
Mar 1, 1989·Topics in Magnetic Resonance Imaging : TMRI·M Brant-Zawadzki
Jan 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·J KesselringW I McDonald
Dec 1, 1987·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K A KraftP R Kishore
Jan 1, 1986·Magnetic Resonance Imaging·M D MitchellP M Joseph
Apr 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D LacomisG Gross
Jan 1, 1985·Radiology·M W VannierM Gado
Sep 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J F HiehleF Gonzalez-Scarano
Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A MacKayD Graeb
Mar 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·J R MitchellA Fenster
Mar 1, 1994·Radiographics : a Review Publication of the Radiological Society of North America, Inc·R I GrossmanM D Schnall
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S J KarlikJ H Noseworthy
Jan 1, 1995·Magnetic Resonance Imaging·P S Tofts
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonG M Pohost
Oct 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M A van BuchemR I Grossman

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Citations

Apr 20, 2004·Brain : a Journal of Neurology·Catherine J ArchibaldJ Ross Mitchell
Apr 13, 2007·IEEE Transactions on Medical Imaging·Xiao Han, Bruce Fischl
Aug 1, 2006·Journal of Magnetic Resonance Imaging : JMRI·Anant MadabhushiGul Moonis
Jan 15, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·Sara RanjbarUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·E A VokurkaA Jackson
Oct 3, 2002·Multiple Sclerosis : Clinical and Laboratory Research·R LeighJ A Frank
Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph F MegyesiJ Gregory Cairncross

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