MR neurography biomarkers to characterize peripheral neuropathy in AL amyloidosis

Neurology
J KollmerUte Hegenbart

Abstract

To detect, localize, and quantify peripheral nerve lesions in amyloid light chain (AL) amyloidosis by magnetic resonance neurography (MRN) in correlation with clinical and electrophysiologic findings. We prospectively examined 20 patients with AL-polyneuropathy (PNP) and 25 age- and sex-matched healthy volunteers. After detailed neurologic and electrophysiologic testing, the patient group was subdivided into mild and moderate PNP. MRN in a 3.0 tesla scanner with anatomical coverage from the lumbosacral plexus and proximal thigh down to the tibiotalar joint was performed by using T2-weighted and dual-echo 2-dimensional sequences with spectral fat saturation and a 3-dimensional, T2-weighted inversion recovery sequence. Besides evaluation of nerve T2-weighted signal, detailed quantification of nerve injury by morphometric (nerve caliber) and microstructural MRN markers (proton spin density, T2 relaxation time) was conducted. Nerve T2-weighted signal increase correlated with disease severity: moderate (420.2 ± 60.1) vs mild AL-PNP (307.2 ± 17.9; p = 0.0003) vs controls (207.0 ± 6.4; p < 0.0001). Proton spin density was also higher in moderate (tibial: 525.5 ± 53.0; peroneal: 553.6 ± 64.5; sural: 492.0 ± 56.6) and mild AL-PNP (tibia...Continue Reading

References

May 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·B T ShahaniJ Cohen
Mar 1, 1982·Journal of the Neurological Sciences·K Sugimura, P J Dyck
Mar 13, 1993·Lancet·A G FillerJ S Tsuruda
Sep 16, 2004·Current Opinion in Neurology·Martin Koltzenburg, Martin Bendszus
Aug 26, 2006·Nature Clinical Practice. Neurology·Martin Bendszus, Guido Stoll
Jan 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Efstathios KastritisGiovanni Palladini
Sep 24, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M MatsudaS Ikeda
Aug 16, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·D AdamsC Lacroix
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Feb 2, 2012·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Marco LuigettiMario Sabatelli
Feb 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shaji KumarMorie A Gertz
Aug 23, 2012·Orphanet Journal of Rare Diseases·Estelle DesportUNKNOWN Centre national de référence pour l’amylose AL et les autres maladies par dépôts d’immunoglobulines monoclonales
Sep 4, 2012·Current Opinion in Neurology·David AdamsCatherine Lacroix
Dec 15, 2012·The Mount Sinai Journal of Medicine, New York·Susan C Shin, Jessica Robinson-Papp
Dec 21, 2014·Brain : a Journal of Neurology·Jennifer KollmerMirko Pham
Sep 16, 2015·Annals of Neurology·Louise-Laure MarianiUNKNOWN French Familial Amyloid Polyneuropathies Network (CORNAMYL) Study Group
Nov 28, 2015·Journal of the American College of Cardiology·Morie A GertzGiampaolo Merlini
Jan 1, 2016·Lancet·Ashutosh D WechalekarPhilip N Hawkins
Jan 23, 2016·Expert Opinion on Pharmacotherapy·David AdamsMarie Théaudin
Oct 13, 2016·Skeletal Radiology·Gavin A McKenzieMichael D Ringler
Dec 3, 2016·Expert Review of Clinical Immunology·Cosimo BruniMarco Matucci-Cerinic

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Citations

Nov 6, 2018·Orphanet Journal of Rare Diseases·Tim W RattayAlexander Grimm
Jan 24, 2020·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Panagiotis KokotisEfstathios Kastritis
Jul 12, 2019·Neurology·Jennifer KollmerMarkus Weiler
Apr 26, 2020·Annals of Clinical and Translational Neurology·Jennifer KollmerMarkus Weiler
Mar 6, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ioannis N PetropoulosRayaz A Malik
Sep 13, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J KollmerM Weiler
Apr 7, 2021·Current Pain and Headache Reports·Chen ZengHan-Feng Yang
May 8, 2021·The British Journal of Radiology·Majid ChalianAvneesh Chhabra
Sep 27, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Christian RotherJennifer Kollmer
Dec 4, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jennifer Kollmer, Martin Bendszus

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