MR perfusion lesions after TIA or minor stroke are associated with new infarction at 7 days

Neurology
Jun LeeJean M Olivot

Abstract

To investigate the relationship between acute perfusion-weighted imaging (PWI) lesions occurring within the first hours after a TIA or a minor brain infarction (BI) and the incidence of new BI detected on a systematic MRI at 1 week. Consecutive patients who experienced a TIA or BI with a neurologic deficit that lasted <24 hours, did not receive any revascularization therapy (thrombolysis/thrombectomy), and underwent DWI/PWI at baseline and fluid-attenuated inversion recovery (FLAIR)/DWI 1 week after symptom onset were enrolled. Investigators blinded to clinical information independently assessed the presence of acute ischemic lesions on baseline DWI/PWI and follow-up DWI and FLAIR. Baseline and follow-up MRIs were then compared to determine the occurrence and location of new infarctions. Sixty-four patients met the inclusion criteria. Median (IQR) ABCD2 score was 4 (3-5). Median delay from onset to baseline and follow-up MRI was 5 (2-10) hours and 6 (5-7) days, respectively. MRI revealed an acute ischemic lesion on DWI and/or PWI in 38 patients. Nine patients (14%) had a new infarction on follow-up MRI. Each had a PWI and 4 had a DWI lesion on baseline MRI. All new BIs except one were asymptomatic and in the same location as th...Continue Reading

References

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Citations

Dec 22, 2017·F1000Research·Camilo R GomezJose Biller
Dec 8, 2017·Stroke; a Journal of Cerebral Circulation·Ivo A MeyerPatrik Michel
Oct 21, 2018·Journal of Neurology·Jae-Hwan ChoiKwang-Dong Choi
Feb 2, 2018·Neurology·Ki-Woong NamByung-Woo Yoon
Sep 27, 2018·Current Atherosclerosis Reports·Carlo W Cereda, Jean-Marc Olivot
Mar 25, 2019·BioMed Research International·Qigu YaoYuyan Zhang
Jan 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Adam E Goldman-YassenSeena Dehkharghani
May 7, 2020·Journal of the Chinese Medical Association : JCMA·Chih-Hsiang LiaoPo-Lin Chen

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