MR studies of retinal oxygenation

Vision Research
Y Ito, B A Berkowitz

Abstract

In this paper, we summarize the development and application of two novel magnetic resonance based measurements of retinal oxygenation in experimental models of retinopathy, including diabetic retinopathy and retinopathy of prematurity. We use 19F-NMR and a small (microl) perfluorocarbon drop positioned in the preretinal vitreous space to make PO2 measurement of the inner retina. In addition, we use magnetic resonance imaging (MRI) to accurately and non-invasively measure the change in the preretinal PO2 (DeltaPO2) following the shift from breathing room air to a hyperoxic inhalation challenge. The advantages and disadvantages of each method are discussed. New applications of these techniques in the newborn rat and adult mouse are presented. We expect such studies to motivate future MRI oxygenation studies of human retinopathy, including diabetic retinopathy and retinopathy of prematurity.

References

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Citations

Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christoph LosertMaximilian Reiser
Oct 13, 2001·NMR in Biomedicine
Jun 5, 2013·Annals of Biomedical Engineering·Isa YildirimMahnaz Shahidi
Jul 24, 2003·Neuroscience Letters·Hideo HoshiTeruya Ohtsuka
Mar 12, 2010·Chemical Reviews·Rizwan Ahmad, Periannan Kuppusamy
Mar 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David C BeebeYing-Bo Shui
Jan 8, 2013·Journal of Biomedical Optics·Sepideh MalekiMahsa Ranji
Feb 18, 2014·Survey of Ophthalmology·J Emanuel Ramos de CarvalhoReinier O Schlingemann
Sep 14, 2007·Current Eye Research·Christina K Chung, Robert A Linsenmeier
Apr 4, 2008·NMR in Biomedicine·Kelly A TownsendJoel S Schuman
Jun 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Greg ZaharchukWilliam P Dillon
Jan 18, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kenneth WenglerXiang He
Apr 11, 2006·Current Eye Research·Mahnaz ShahidiRoss D Shonat
Apr 6, 2020·Acta Ophthalmologica·Aumer ShughouryAlon Harris
Jul 1, 2017·Biomedical Optics Express·Siyu ChenHao F Zhang
Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Laura Pop-FaneaJanet Liversidge

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