PMID: 2861880Jul 13, 1985Paper

MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party

British Medical Journal

Abstract

The main aim of the trial was to determine whether drug treatment of mild hypertension (phase V diastolic pressure 90-109 mm Hg) reduced the rates of stroke, of death due to hypertension, and of coronary events in men and women aged 35-64 years. Subsidiary aims were: to compare the course of blood pressure in two groups, one taking bendrofluazide and one taking propranolol, and to compare the incidence of suspected adverse reactions to these two drugs. The study was single blind and based almost entirely in general practices; 17 354 patients were recruited, and 85 572 patient years of observation have accrued. Patients were randomly allocated at entry to take bendrofluazide or propranolol or placebo tablets. The primary results were as follows. The stroke rate was reduced on active treatment: 60 strokes occurred in the treated group and 109 in the placebo group, giving rates of 1.4 and 2.6 per 1000 patient years of observation respectively (p less than 0.01 on sequential analysis). Treatment made no difference, however, to the overall rates of coronary events: 222 events occurred on active treatment and 234 in the placebo group (5.2 and 5.5 per 1000 patient years respectively). The incidence of all cardiovascular events was red...Continue Reading

References

Jan 5, 1985·British Medical Journal·S J Pocock
Feb 14, 1970·Lancet·B M Wright, C F Dore
Mar 7, 1970·Lancet·A B Carter
Sep 7, 1974·British Medical Journal·W E Miall, S Chinn
Sep 1, 1983·The American Journal of Medicine·P J Toth, R I Horwitz
Oct 2, 1982·British Medical Journal·P J BrennanS G Thompson
Mar 1, 1981·Hypertension·M H Alderman, S Madhavan
Feb 8, 1964·Lancet·G A ROSEE A CROWLEY

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Citations

Aug 14, 2001·Pharmazie in unserer Zeit·U HeemannT Phillip
Mar 1, 1990·Clinical Cardiology·M LehmannA Schmid
Jan 1, 1992·Clinical Cardiology·D Georgiou, B H Brundage
Jun 1, 1995·Clinical Cardiology·M Epstein
Oct 1, 1995·Diabetes/metabolism Reviews·C F Close, R E Ryder
Feb 1, 1990·Journal of Clinical Pharmacology·L M PrisantC G Hames
Mar 1, 1993·Journal of Clinical Pharmacology·J SombergS Khosla
Jan 1, 1997·Cardiovascular Drugs and Therapy·L H Opie
Dec 1, 1992·Cardiovascular Drugs and Therapy·L H Opie
Dec 1, 1992·Cardiovascular Drugs and Therapy·M Moser
Dec 1, 1991·Cardiovascular Drugs and Therapy·J D Swales
Dec 1, 1991·Cardiovascular Drugs and Therapy·J R Hampton
Jun 1, 1989·Cardiovascular Drugs and Therapy·A J CoatsP Sleight
Jun 1, 1989·Cardiovascular Drugs and Therapy·M D Feher, D J Betteridge
Jan 1, 1988·European Journal of Clinical Pharmacology·K F WhyteJ L Reid
Jan 1, 1987·European Journal of Clinical Pharmacology·V A NaukkarinenS Sarna
Aug 1, 1994·Cardiovascular Drugs and Therapy·J I Robertson
Jan 1, 1988·European Journal of Clinical Pharmacology·P GroomP D Richardson
Jul 5, 1990·Klinische Wochenschrift·A M SharmaA Distler
Dec 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·D A SclarM A Gill
Oct 1, 1989·Cardiovascular Drugs and Therapy·J R Hampton
Oct 1, 1989·Cardiovascular Drugs and Therapy·J I Robertson
Oct 1, 1989·Cardiovascular Drugs and Therapy·H K Bali, I S Anand
Dec 1, 1989·Cardiovascular Drugs and Therapy·I J Perry, D G Beevers
Dec 1, 1989·Cardiovascular Drugs and Therapy·W J Louis
Dec 1, 1989·Cardiovascular Drugs and Therapy·K Arakawa
Dec 1, 1990·Cardiovascular Drugs and Therapy·R E Schmieder, J K Rockstroh
Nov 1, 1987·Journal of General Internal Medicine·W Engel, J Sawyer
Nov 1, 1987·Journal of General Internal Medicine·C H Hennekens
Nov 1, 1987·Journal of General Internal Medicine·A Gafni
Nov 1, 1987·Journal of General Internal Medicine·P D Levinson, R A Carleton

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